TY  - JOUR
AU  - García-Fernández, M.J.
AU  - Tabary, N.
AU  - Martel, B.
AU  - Cazaux, F.
AU  - Oliva, A.
AU  - Taboada, P.
AU  - Concheiro, A.
AU  - Alvarez-Lorenzo, C.
T1  - Poly-(cyclo)dextrins as ethoxzolamide carriers in ophthalmic solutions and in contact lenses
LA  - eng
PY  - 2013
SP  - 1343
EP  - 1352
T2  - Carbohydrate Polymers
SN  - 0144-8617
VL  - 98
IS  - 2
AB  - Efficient ophthalmic therapy requires the development of strategies that can provide sufficiently high drug levels in the ocular structures for a prolonged time. This work focuses on the suitability of poly-(cyclo)dextrins as carriers able to solubilize the carbonic anhydrase inhibitor (CAI) ethoxzolamide (ETOX), which is so far used for oral treatment of glaucoma. Topical ocular treatment should notably enhance the efficiency/safety profile of the drug. Natural α-, β- and γ-cyclodextrins and a maltodextrin were separately polymerized using citric acid as cross-linker agent under mild conditions. The resultant hydrophilic polymers exhibited larger capability to solubilize ETOX than the pristine (cyclo)dextrins. Moreover, they provided sustained drug diffusion in artificial lachrymal fluid. Interestingly the poly-(cyclo)dextrins solutions facilitate the loading of remarkably high doses of ETOX in poly(2-hydroxyethyl methacrylate)-based contact lenses. Exploiting ionic interactions between functional groups in the contact lenses and remnant free carboxylic acids in the citric acid linkers of poly-(cyclo)dextrins led to the retention of the drug-loaded poly-(cyclo)dextrins and, in turn, to sustained release for several weeks. © 2013 Elsevier Ltd. All rights reserved.
DO  - 10.1016/j.carbpol.2013.08.003
UR  - https://portalciencia.ull.es/documentos/5d9da96e299952484ef7e308
DP  - Dialnet - Portal de la Investigación
ER  -