TY  - JOUR
AU  - Rodríguez-Évora, M.
AU  - Reyes, R.
AU  - Alvarez-Lorenzo, C.
AU  - Concheiro, A.
AU  - Delgado, A.
AU  - Évora, C.
T1  - Bone regeneration induced by an in situ gel-forming poloxamine, bone morphogenetic protein-2 system
LA  - eng
PY  - 2014
SP  - 959
EP  - 969
T2  - Journal of Biomedical Nanotechnology
SN  - 1550-7041
VL  - 10
IS  - 6
PB  - American Scientific Publishers
AB  - The aim of this study was to confirm previously shown, in vitro osteogenic induction by the Tetronics T908 and T1307 in a critical-size, rat calvaria defect. In vivo, the osteogenic activity of the hydrogels was comparable to in vitro, but less pronounced. However, similar to in vitro, the system was strongly potentiated by incorporating 6.5 μg of bone morphogenetic protein-2 in solution or pre-encapsulated in poly(lactic-co-glycolic) acid microspheres. These two systems extended the in vivo release of bone morphogenetic protein-2, determined with 125I- bone morphogenetic protein-2, for one and two additional weeks, respectively, time enough to fill approximately 40% and 90% of the defect with well-organized bone. Furthermore, the structural characteristics of Tetronic hydrogels together with their biocompatibility, injectability, and adaptability to multiple defect sizes and shapes suggest their role as new, potential bone morphogenetic protein-2 delivery, low-cost scaffolds for minor as well as critical bone defects. Copyright © 2014 American Scientific Publishers All rights reserved.
DO  - 10.1166/JBN.2014.1801
UR  - https://portalciencia.ull.es/documentos/5d9dab8d299952484ef7f75f
DP  - Dialnet - Portal de la Investigación
ER  -