TY  - JOUR
AU  - Del Rosario, C.
AU  - Rodríguez-Évora, M.
AU  - Reyes, R.
AU  - Simões, S.
AU  - Concheiro, A.
AU  - Évora, C.
AU  - Alvarez-Lorenzo, C.
AU  - Delgado, A.
T1  - Bone critical defect repair with poloxamine-cyclodextrin supramolecular gels
LA  - eng
PY  - 2015
SP  - 463
EP  - 473
T2  - International Journal of Pharmaceutics
SN  - 1873-3476
VL  - 495
IS  - 1
PB  - Elsevier
AB  - The aim of this study was to evaluate the osteoinductive capacity of a poloxamine (Tetronic<sup>®</sup> 908, T) and α-cyclodextrin (αCD) supramolecular gel (T-CD) as scaffold in a critical size defect in rat calvaria. The T-CD gel was evaluated solely and after being loaded with simvastatin (SV) and bone morphogenetic protein (BMP-2) separately and in combinations in order to reduce the doses of the active substances. Three doses of SV (7.5, 75, 750 μg) and two doses of BMP-2 (3 and 6 μg) were tested. The histology and histomorphometrical analysis showed improved bone repair with T-CD compared to T, probably due to better release control of both SV and BMP-2. In addition, as T-CD eroded more slowly than poloxamine alone, it remained longer in the defect site. Although synergism was not obtained with BMP-2 and SV, according to the observed regeneration of the defect, the dose of BMP-2 and SV can be reduced to 3 μg and 7.5 μg, respectively.
DO  - 10.1016/J.IJPHARM.2015.09.003
UR  - https://portalciencia.ull.es/documentos/5d9dac1d299952484ef7fcbe
DP  - Dialnet - Portal de la Investigación
ER  -