Development of analytical methodologies for the determination of compounds with oestrogenic activity

Résumé

In this PhD Thesis, different sensitive and environmentally friendly analytical methodologies have been developed for the analysis of a wide group of oestrogenic compounds in environmental and food samples of diverse nature. With this aim, selective extraction techniques, including hollow-fibre liquid-phase microextraction, dispersive liquid-liquid microextraction using ionic liquids, the QuEChERS method and magnetic and non-magnetic micro-dipersive solid-phase extraction using diverse nanomaterials, have been applied. These procedures have been combined with different liquid chromatographic systems such as high-performance liquid chromatography and ultra-high-performance liquid chromatography for the separation and determination of the target compounds using diode array, fluorescence and tandem mass spectrometry detectors.