Los canales de agua. Acuaporinas 1 y 4 en el sistema nervioso central y su relación con la hidrocefalia

  1. Leandro Castañeyra Ruiz
  2. Ibrahim González Marrero
  3. María Castañeyra Ruiz
  4. Juan M. González Toledo
  5. Emilia María Carmona Calero
Majorensis: Revista Electrónica de Ciencia y Tecnología

ISSN: 1697-5529

Ano de publicación: 2014

Número: 10

Páxinas: 1-6

Tipo: Artigo


Water channels. Aquaporins 1 and 4 in the central nervous system and its relation to the hydrocephalus. Aquaporins are membrane-bound water channel and highly related to the development and resolution of brain edema. Aquaporin-1(AQP1) is highly expressed at the choroid plexus and is related to CSF production. Aquaporin-4 (AQP4) is a water channel mainly located in the end-feet of astrocytes in the subependymal and ependymal ventricular layer, the blood-brain barrier (BBB). Hydrocephalus is an accumulation of the cerebrospinal fluid (CSF) with dilatation of brain ventricles which can be either communicating or non-communicating. Hydrocephalus is due to multiple pathophysiological mechanisms, with many different causes including birth defects, brain hemorrhage, infection, meningitis, tumor, or head injury. The choroid plexus (ChP), other circumventricular structures and aquaporins are closely related to the above-mentioned pathophysiological mechanisms of the hydrocephalis. The studies analyzed in this revision showed that, there are variations in the AQP1 and AQP4 in the ChP, BBB and CSF that could mean compensatory effect of the hydrocephalus.