TY  - JOUR
AU  - Dominguez-Rodriguez, A.
AU  - Kaski, J.C.
AU  - Abreu-Gonzalez, P.
AU  - Samimi-Fard, S.
T1  - Role of ischemia modified albumin to ST-segment resolution after mechanical reperfusion in patients with ST-segment elevation myocardial infarction
LA  - eng
PY  - 2009
SP  - 576
EP  - 580
T2  - Atherosclerosis
SN  - 0021-9150
VL  - 203
IS  - 2
AB  - Objective: To investigate the possible association between admission ischemia modified albumin (IMA) levels and ST-segment resolution (STR) in ST-segment elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (PCI). Materials and Methods: We studied 117 patients with a first STEMI within 6 h of the onset of pain. Admission serum IMA concentration was measured using a validated assay. The worst single electrocardiogram lead before and 90 min after primary PCI was analyzed, and patients were divided into two groups according to the degree of STR: complete (≥70%) or incomplete (<70%). Results: Of the 117 patients, 70 (60%) had complete STR, and 47 (40%) incomplete STR. Serum IMA concentrations were significantly higher in patients that had incomplete STR (0.383 ± 0.060 A.U. vs. 0.297 ± 0.056 A.U., p < 0.001). IMA levels >0.325 A.U. demonstrated a sensitivity of 91.4% and a specificity of 45.7% for the diagnosis of incomplete STR; the area under the receiver operator characteristic curve was 0.849 (95% CI 0.77-0.92, p = 0.0001). Moreover, IMA values were an independent predictor of incomplete STR even after adjustment for potential confounders (OR 2.34; 95% CI 1.20-4.64, p = 0.01). Conclusions: IMA may be a useful biomarker for the identification of incomplete STR in STEMI patients presenting to hospital within 6 h of the onset of pain. © 2008 Elsevier Ireland Ltd. All rights reserved.
DO  - 10.1016/j.atherosclerosis.2008.07.033
UR  - https://portalciencia.ull.es/documentos/5e39b7482999523aa92711d9
DP  - Dialnet - Portal de la Investigación
ER  -