TY  - JOUR
AU  - Latouche, C.
AU  - El Moghrabi, S.
AU  - Messaoudi, S.
AU  - Cat, A.N.D.
AU  - Hernandez-Diaz, I.
AU  - De La Rosa, D.A.
AU  - Perret, C.
AU  - Andrés, N.L.
AU  - Rossignol, P.
AU  - Zannad, F.
AU  - Farman, N.
AU  - Jaisser, F.
T1  - Neutrophil gelatinase-associated lipocalin is a novel mineralocorticoid target in the cardiovascular system
LA  - eng
PY  - 2012
SP  - 966
EP  - 972
T2  - Hypertension
SN  - 0194-911X
VL  - 59
IS  - 5
AB  - Mineralocorticoid receptor (MR) activation may be deleterious to the cardiovascular system, and MR antagonists improve morbidity and mortality of patients with heart failure. However, mineralocorticoid signaling in the heart remains largely unknown. Using a pan-genomic transcriptomic analysis, we identified neutrophil gelatinase-associated lipocalin (NGAL or lipocalin 2) as a strongly induced gene in the heart of mice with conditional and targeted MR overexpression in cardiomyocytes (whereas induction was low in glucocorticoid receptor-overexpressing mice). NGAL mRNA levels were enhanced after hormonal stimulation by the MR ligand aldosterone in cultured cardiac cells and in the heart of wild-type mice. Mineralocorticoid pathological challenge induced by nephrectomy/aldosterone/salt treatment upregulated NGAL expression in the heart and aorta and its plasma levels. We show evidence for MR binding to an NGAL promoter, providing a mechanism for NGAL regulation. We propose that NGAL may be a marker of mineralocorticoid-dependent injury in the cardiovascular system in mice. © 2012 American Heart Association, Inc.
DO  - 10.1161/HYPERTENSIONAHA.111.187872
UR  - https://portalciencia.ull.es/documentos/5e39b7672999523aa92712dd
DP  - Dialnet - Portal de la Investigación
ER  -