TY  - JOUR
AU  - Marin, R.
AU  - Fabelo, N.
AU  - Fernández-Echevarría, C.
AU  - Canerina-Amaro, A.
AU  - Rodríguez-Barreto, D.
AU  - Quinto-Alemany, D.
AU  - Mesa-Herrera, F.
AU  - Díaz, M.
T1  - Lipid raft alterations in aged-associated neuropathologies
LA  - eng
PY  - 2016
SP  - 973
EP  - 984
T2  - Current Alzheimer Research
SN  - 1875-5828
VL  - 13
IS  - 9
PB  - Bentham Science Publishers B.V.
PP  - Bussum
AB  - Lipid rafts are membrane microdomains particularly enriched in cholesterol, sphingolipids and saturated fatty acids. These microstructures play a key role in a plethora of mechanisms involved in cell signaling, synapsis, cell-cell communication and cell survival. In the last years, increasing evidence indicate that lipid rafts may be altered in age-related neuropathologies, such as Alzheimer’s disease and Parkinson disease even at asymptomatic stages. In particular, important changes in raft lipid composition are observed with the progression of these diseases, then inducing alterations in their physicochemical properties. Furthermore, these phenomena contribute to neuropathological events related to amyloidogenesis, aberrant protein aggregation and toxic cell signalling. In this review, we discuss some relevant data on the age-related molecular changes occurring in lipid rafts since the first stages of these neurodegenerative diseases. Further characterization of specific parameters associated with alterations of these microdomains may provide potential tools of diagnosis and prediction of these neuropathologies.
DO  - 10.2174/1567205013666160314150017
UR  - https://portalciencia.ull.es/documentos/5e39b76c2999523aa9271307
DP  - Dialnet - Portal de la Investigación
ER  -