TY  - JOUR
AU  - Castañeyra-Perdomo, A.
AU  - Carmona-Calero, E.
AU  - Meyer, G.
AU  - Pérez-González, H.
AU  - Del Mar Pérez-Delgado, M.
AU  - Marrero-Gordillo, N.
AU  - Rodríguez, S.
AU  - Rodríguez, E.M.
T1  - Changes in the secretory activity of the subcommissural organ of spontaneously hypertensive rats
LA  - eng
PY  - 1998
SP  - 133
EP  - 136
T2  - Neuroscience Letters
SN  - 0304-3940
VL  - 246
IS  - 3
AB  - The subcommissural organ (SCO) is a glandular circumventricular organ secreting glycoproteins into the cerebrospinal fluid. The SCO of 15-week-old spontaneously hypertensive rats (SHR) and of matched normotensive Wistar- Kyoto rats (WKY) was studied immunocytochemically by using an antibody against the glycoproteins secreted by the SCO. The blood pressure, water intake and volume of brain ventricles of SHR and WKY rats were also recorded. The SHR were hypertensive, drank more water and did not display dilatation of the brain ventricles. The SCO of the SHR rats showed a drastic decrease of the immunoreactive material stored in the rough endoplasmic reticulum whereas the amount of immunoreactive apical secretory granules did not vary with respect to the SCO of WKY rats. These changes are compatible with an increased secretory activity of the SCO of the SHR rats. It is suggested that the changes in the SCO of SHR rats, and their hypertensive state, are interrelated phenomena.
DO  - 10.1016/S0304-3940(98)00252-3
UR  - https://portalciencia.ull.es/documentos/5e39b76f2999523aa927131f
DP  - Dialnet - Portal de la Investigación
ER  -