TY  - JOUR
AU  - Plata-Bello, J.
AU  - Modroño, C.
AU  - Acosta-López, S.
AU  - Pérez-Martín, Y.
AU  - Marcano, F.
AU  - García-Marín, V.
AU  - González–Mora, J.L.
T1  - Subarachnoid hemorrhage and visuospatial and visuoperceptive impairment: disruption of the mirror neuron system
LA  - eng
PY  - 2017
SP  - 1538
EP  - 1547
T2  - Brain Imaging and Behavior
SN  - 1931-7565
VL  - 11
IS  - 5
PB  - Springer New York LLC
AB  - Nearly 20 % of patients who suffer a subarachnoid hemorrhage (SAH) still display cognitive impairment even a year after follow-up. Visuospatial and visuoperceptive domains may be impaired in this cognitive impairment and may not have been fully studied in these patients. Furthermore, these cognitively impaired domains have been associated with activity in the so-called mirror neuron system (MNS). The aim of the study is to analyze the pattern of brain activity with an MNS task-based functional magnetic resonance imaging (fMRI) study in SAH patients. A complete neuropsychological assessment and fMRI study (with observation and execution conditions) were performed in patients with a history of SAH registered in the database of the Hospital Universitario de Canarias and a healthy control group. The patients had to meet all the following inclusion criteria for the study (less than 50 years old; SAH with a Fisher score 1–3; no vasospasm or ischemia; minimum follow-up of one year). Twelve SAH patients were studied. Three of which displayed visuospatial/visuoperceptive impairment. fMRI study showed the presence of higher activity in MNS regions in these patients than in patients with normal visuospatial/visuoperceptive functions. Furthermore, there was a negative correlation between the test scores and brain activity in premotor regions of the studied patients. SAH patients with visuospatial/visuoperceptive impairment have greater activity in the MNS regions. This finding may be associated with a subcortical dysfunction, leading to a disruption of neural activity and less efficient behavior of this brain network.
DO  - 10.1007/s11682-016-9609-3
UR  - https://portalciencia.ull.es/documentos/5e39b79a2999523aa927149a
DP  - Dialnet - Portal de la Investigación
ER  -