TY  - GEN
AU  - Francis, M.J.O.
AU  - Lees, R.L.
AU  - Trujillo, E.
AU  - Martín-Vasallo, P.
AU  - Heersche, J.N.M.
AU  - Mobasheri, A.
T1  - ATPase pumps in osteoclasts and osteoblasts
LA  - eng
PY  - 2002
SP  - 459
EP  - 476
T2  - International Journal of Biochemistry and Cell Biology
SN  - 1357-2725
VL  - 34
IS  - 5
AB  - Osteoblasts, osteocytes and osteoclasts are specialised cells of bone that play crucial roles in the formation, maintenance and resorption of bone matrix. Bone formation and resorption critically depend on optimal intracellular calcium and phosphate homeostasis and on the expression and activity of plasma membrane transport systems in all three cell types. Osteotropic agents, mechanical stimulation and intracellular pH are important parameters that determine the fate of bone matrix and influence the activity, expression, regulation and cell surface abundance of plasma membrane transport systems. In this paper the role of ATPase pumps is reviewed in the context of their expression in bone cells, their contribution to ion homeostasis and their relation to other transport systems regulating bone turnover. © 2002 Elsevier Science Ltd. All rights reserved.
DO  - 10.1016/S1357-2725(01)00142-X
UR  - https://portalciencia.ull.es/documentos/5e3adc82299952629a024754
DP  - Dialnet - Portal de la Investigación
ER  -