TY  - JOUR
AU  - Díaz-Gómez, N.M.
AU  - Doménech, E.
AU  - Barroso, F.
AU  - Castells, S.
AU  - Cortabarria, C.
AU  - Jiménez, A.
T1  - The effect of zinc supplementation on linear growth, body composition, and growth factors in preterm infants
LA  - eng
PY  - 2003
SP  - 1002
EP  - 1009
T2  - Pediatrics
SN  - 0031-4005
VL  - 111
IS  - 5 I
AB  - Objective. The aim of our study was to evaluate the effect of zinc supplementation on linear growth, body composition, and growth factors in premature infants. Design. Thirty-six preterm infants (gestational age: 32.0 ± 2.1 weeks, birth weight: 1704 ± 364 g) participated in a longitudinal double-blind, randomized clinical trial. They were randomly allocated either to the supplemental (S) group fed with a standard term formula supplemented with zinc (final content 10 mg/L) and a small quantity of copper (final content 0.6 mg/L), or to the placebo group fed with the same formula without supplementation (final content of zinc: 5 mg/L and copper: 0.4 mg/L), from 36 weeks postconceptional age until 6 months corrected postnatal age. At each evaluation, anthropometric variables and bioelectrical impedance were measured, a 3-day dietary record was collected, and a blood sample was taken. We analyzed serum levels of total alkaline phosphatase, skeletal alkaline phosphatase (sALP), insulin growth factor (IGF)-I, IGF binding protein-3, IGF binding protein-1, zinc and copper, and the concentrations of zinc in erythrocytes. Results. The S group had significantly higher zinc levels in serum and erythrocytes and lower serum copper levels with respect to the placebo group. We found that the S group had a greater linear growth (from baseline to 3 months corrected age: Δ score deviation standard length: 1.32 ± .8 vs .38 ± .8). The increase in total body water and in serum levels of sALP was also significantly higher in the S group (total body water: 3 months; corrected age: 3.8 ± .5 vs 3.5 ± .4 kg, 6 months; corrected age: 4.5 ± .5 vs 4.2 ± .4 kg; sALP: 3 months; corrected age: 140.2 ± 28.7 vs 118.7 ± 18.8 μg/L). Conclusions. Zinc supplementation has a positive effect on linear growth in premature infants.
DO  - 10.1542/peds.111.5.1002
UR  - https://portalciencia.ull.es/documentos/5e3adccc299952629a0249d5
DP  - Dialnet - Portal de la Investigación
ER  -