TY  - JOUR
AU  - Bujanda, L.
AU  - Sarasqueta, C.
AU  - Lanas, Á.
AU  - Quintero, E.
AU  - Cubiella, J.
AU  - Hernandez, V.
AU  - Morillas, J.D.
AU  - Perez-Fernández, T.
AU  - Salas, D.
AU  - Andreu, M.
AU  - Carballo, F.
AU  - Bessa, X.
AU  - Portillo, I.
AU  - Jover, R.
AU  - Balaguer, F.
AU  - Cosme, A.
AU  - Castells, A.
T1  - Effect of oral anticoagulants on the outcome of faecal immunochemical test
LA  - eng
PY  - 2014
SP  - 1334
EP  - 1337
T2  - British Journal of Cancer
SN  - 1532-1827
VL  - 110
IS  - 5
PB  - Nature Publishing Group
PP  - Basingstoke, Hampshire
AB  - Background: We aimed to evaluate whether oral anticoagulants (OACs) alter faecal immunochemical test (FIT) performance in average-risk colorectal cancer (CRC) screening. Methods: Individuals aged 50-69 years were invited to receive one FIT sample (cutoff 75 ng ml -1) between November 2008 and June 2011. Results: Faecal immunochemical test was positive in 9.3% (21 out of 224) of users of OAC and 6.2% (365 out of 5821) of non-users (P-trend=0.07). The positive predictive value (PPV) for advanced neoplasia (AN) in non-users was 50.4% vs 47.6% in users (odds ratio, 0.70; 95% CI, 0.3-1.8; P=0.5). The PPV for AN in OAC more antiplatelets (aspirin or clopidogrel) was 75% (odds ratio, 2; 95% CI, 0.4-10.8; P=0.4). Conclusions: Oral anticoagulant did not significantly modify the PPV for AN in this population-based colorectal screening program. The detection rate of advanced adenoma was higher in the combination OAC more antiplatelets. © 2014 Cancer Research UK.
DO  - 10.1038/BJC.2014.38
UR  - https://portalciencia.ull.es/documentos/5e3c396729995246bbf5f363
DP  - Dialnet - Portal de la Investigación
ER  -