TY  - JOUR
AU  - Marcelino Rodríguez, I.
AU  - Oliva García, J.
AU  - Alemán Sánchez, J.J.
AU  - Almeida González, D.
AU  - Domínguez Coello, S.
AU  - Brito Díaz, B.
AU  - Gannar, F.
AU  - Rodríguez Pérez, M.C.
AU  - Elosua, R.
AU  - Cabrera de León, A.
T1  - Lipid and inflammatory biomarker profiles in early insulin resistance
LA  - eng
PY  - 2016
SP  - 905
EP  - 913
T2  - Acta Diabetologica
SN  - 1432-5233
VL  - 53
IS  - 6
PB  - Springer-Verlag Italia s.r.l.
AB  - Aims: To analyze the serum lipid and inflammatory biomarker profile in the early insulin resistance (e-IR). Methods: Cross-sectional study of 5943 adults without diabetes, stratified into no IR group (C-peptide <third tertile and glucose <100 mg/dL), e-IR group (C-peptide ≥third tertile and glucose <100 mg/dL) and advanced IR group (glucose ≥100 mg/dL). Results: E-IR showed significant differences with no IR in the serum concentration of triglycerides (P < 0.001), HDL cholesterol (P < 0.001), LDL cholesterol (P < 0.001), sCD40L (P < 0.001), C-reactive protein (P < 0.004), leptin (P < 0.001) and adiponectin (P < 0.001). Adjusting for age, gender and abdominal obesity, corroborated the association of e-IR with highest quintile of triglycerides (OR 3.88 [3.07–4.89]), HDL cholesterol (OR 0.35 [0.28–0.44]), sCD40L (OR 0.47 [0.24–0.94]), C-reactive protein (OR 2.31 [1.29–4.12]), adiponectin (OR 0.11 [0.04–0.32]), PAI-1 (OR 3.29 [1.29–8.40]) and resistin (OR 1.25 [1.01–1.54]); the same biomarkers were associated with advanced IR although resistin was a protective factor (OR 0.73 [0.58–0.93]). Conclusions: Euglycemic patients with e-IR present an unfavorable serum lipid and inflammatory biomarker profile. Measuring C-peptide in euglycemic patients with elevated triglycerides identifies e-IR.
DO  - 10.1007/s00592-016-0885-6
UR  - https://portalciencia.ull.es/documentos/5e3c3b5129995246bbf60061
DP  - Dialnet - Portal de la Investigación
ER  -