TY  - JOUR
AU  - Oramas-Royo, S.
AU  - Pantoja, K.D.
AU  - Amesty, Á.
AU  - Romero, C.
AU  - Lorenzo-Castrillejo, I.
AU  - Machín, F.
AU  - Estévez-Braun, A.
T1  - Synthesis and antibacterial activity of new symmetric polyoxygenated dibenzofurans
LA  - eng
PY  - 2017
SP  - 178
EP  - 187
T2  - European Journal of Medicinal Chemistry
SN  - 1768-3254
VL  - 141
PB  - Elsevier Masson SAS
PP  - Issy les Moulineaux Cedex
AB  - A series of symmetric polyoxygenated dibenzofurans with 2-methylbutyril moieties at C-4 and C-6 were obtained from commercial phloroglucinol through a sequence of reactions that include monoacylation, iodination, Suzuki-Miyaura coupling, oxidative dimerization and cyclization. Some of the compounds obtained were active against Gram-positive bacteria, including multiresistant Staphylococcus aureus clinical isolates. The dibenzofuran 28 with propyl chains at C-2 and C-8 exhibited the best antibacterial activity with values comparable to those of the natural dibenzofuran achyrofuran. From the obtained results some structure-activity relationships were outlined.
DO  - 10.1016/j.ejmech.2017.09.062
UR  - https://portalciencia.ull.es/documentos/5e3c3c8b29995246bbf6082a
DP  - Dialnet - Portal de la Investigación
ER  -