TY - JOUR AU - Oramas-Royo, S. AU - Pantoja, K.D. AU - Amesty, Á. AU - Romero, C. AU - Lorenzo-Castrillejo, I. AU - Machín, F. AU - Estévez-Braun, A. T1 - Synthesis and antibacterial activity of new symmetric polyoxygenated dibenzofurans LA - eng PY - 2017 SP - 178 EP - 187 T2 - European Journal of Medicinal Chemistry SN - 1768-3254 VL - 141 PB - Elsevier Masson SAS PP - Issy les Moulineaux Cedex AB - A series of symmetric polyoxygenated dibenzofurans with 2-methylbutyril moieties at C-4 and C-6 were obtained from commercial phloroglucinol through a sequence of reactions that include monoacylation, iodination, Suzuki-Miyaura coupling, oxidative dimerization and cyclization. Some of the compounds obtained were active against Gram-positive bacteria, including multiresistant Staphylococcus aureus clinical isolates. The dibenzofuran 28 with propyl chains at C-2 and C-8 exhibited the best antibacterial activity with values comparable to those of the natural dibenzofuran achyrofuran. From the obtained results some structure-activity relationships were outlined. DO - 10.1016/J.EJMECH.2017.09.062 UR - https://portalciencia.ull.es/documentos/5e3c3c8b29995246bbf6082a DP - Dialnet - Portal de la Investigación ER -