TY  - JOUR
AU  - Cen-Pacheco, F.
AU  - Manríquez, C.P.
AU  - Souto, M.L.
AU  - Norte, M.
AU  - Fernández, J.J.
AU  - Daranas, A.H.
T1  - Marine longilenes, oxasqualenoids with ser-thr protein phosphatase 2A inhibition activity
LA  - eng
PY  - 2018
T2  - Marine Drugs
SN  - 1660-3397
VL  - 16
IS  - 4
PB  - MDPI AG
PP  - Basel
AB  - The red seaweed Laurencia viridis is a rich source of oxygenated secondary metabolites that were derived from squalene. We report here the structures of three novel compounds, (+)-longilene peroxide (1), longilene (2), and (+)-prelongilene (3) that were isolated from this alga, in addition to other substances, 4 and 5, resulting from their acid-mediated degradation. The effect of compounds 1 and 3 against Ser-Thr protein phosphatase type 2A (PP2A) was evaluated, showing that (+)-longilene peroxide (1) inhibited PP2A (IC50 11.3 µM). In order to explain the interaction between PP2A and compounds 1 and 3, molecular docking simulations onto the PP2A enzyme-binding region were used.
DO  - 10.3390/MD16040131
UR  - https://portalciencia.ull.es/documentos/5e3c3ee129995246bbf613ed
DP  - Dialnet - Portal de la Investigación
ER  -