TY  - JOUR
AU  - Bayer, C.L.
AU  - Herrero, É.P.
AU  - Peppas, N.A.
T1  - Alginate films as macromolecular imprinted matrices
LA  - eng
PY  - 2011
SP  - 1523
EP  - 1534
T2  - Journal of Biomaterials Science, Polymer Edition
SN  - 1568-5624
VL  - 22
IS  - 11
PB  - Taylor and Francis Inc.
AB  - Macromolecularly imprinted polymers have been developed to mimic the non-covalent interactions driving molecular recognition in nature. The creation of an engineered antibody mimic would allow for the development of customizable films for biomolecular sensing. To demonstrate this principle, a cross-linked alginate film has been imprinted with bovine serum albumin (BSA) using aqueous biocompatible gelation methods. The imprinting efficiency of the synthesized films imprinted with BSA was determined and compared to the non-specific uptake of complementary proteins which were not imprinted in the alginate matrix. It was found that the recognition of the BSA using an alginate film was 6.4 mg/g polymer, which compares favorably to previously reported macromolecularly imprinted networks. The absorption of non-imprinted cationic proteins by the alginate matrix demonstrates that overcoming non-specific binding needs to be a focus of future work in order to successfully employ these materials towards biomolecular sensing within a physiological environment. © 2011 Koninklijke Brill NV, Leiden.
DO  - 10.1163/092050610X514115
UR  - https://portalciencia.ull.es/documentos/5e6952902999522cccdcf0f8
DP  - Dialnet - Portal de la Investigación
ER  -