TY  - JOUR
AU  - Valdés-Baizabal, C.
AU  - Parras, G.G.
AU  - Ayala, Y.A.
AU  - Malmierca, M.S.
T1  - Endocannabinoid Modulation of Stimulus-Specific Adaptation in Inferior Colliculus Neurons of the Rat
LA  - eng
PY  - 2017
T2  - Scientific Reports
SN  - 2045-2322
VL  - 7
IS  - 1
PB  - Nature Publishing Group
PP  - Basingstoke, Hampshire
AB  - Cannabinoid receptors (CBRs) are widely distributed in the brain, including the inferior colliculus (IC). Here, we aim to study whether endocannabinoids influence a specific type of neuronal adaptation, namely, stimulus-specific adaptation (SSA) found in some IC neurons. SSA is important because it has been found as early as the level of the midbrain and therefore it may be a neuronal correlate of early indices of deviance detection. Furthermore, recent studies have demonstrated a direct link between SSA and MMN, that is widely used as an outcome measure in a variety of human neurodegenerative disorders. SSA is considered a form of short-term plasticity, and CBRs have been shown to play a role in short-term neural plasticity. Therefore, it is reasonable to hypothesize that endocannabinoids may play a role in the generation or modulation of SSA. We recorded single units in the IC under an oddball paradigm stimulation. The results demonstrate that cannabinoid agonists lead to a reduction in the neuronal adaptation. This change is due to a differential increase of the neuronal firing rate to the standard tone alone. Furthermore, we show that the effect is mediated by the cannabinoid receptor 1 (CBR1). Thus, cannabinoid agonists down-modulate SSA in IC neurons.
DO  - 10.1038/s41598-017-07460-w
UR  - https://portalciencia.ull.es/documentos/5e6958eb2999522cccdd1b47
DP  - Dialnet - Portal de la Investigación
ER  -