TY - JOUR AU - Cabrera, J. AU - Inglada, L. AU - Quintero, E. AU - Jimenez, W. AU - Losada, A. AU - Mayor, J. AU - Guerra, C. T1 - Large‐volume paracentesis and intravenous saline: Effects on the renin‐angiotensin system LA - eng PY - 1991 SP - 1025 EP - 1028 T2 - Hepatology SN - 1527-3350 VL - 14 IS - 6 AB - Fourteen cirrhotic patients with tense ascites were treated with total paracentesis and intravenous isotonic saline infusion. Standard liver and kidney function tests, plasma renin activity and aldosterone concentration were measured before, at 48 hrs and at 7 days after total paracentesis. The volume of ascites removed was 7.7 ± 5.6 1 (mean ± S.E.M.). None of the treated patients had clinical complications or significant alterations in liver or kidney function test results. Paracentesis and intravenous isotonic saline infusion were not associated with significant changes in mean plasma renin activity or plasma aldosterone concentration. These results suggest that this therapeutic procedure could be a safe and cost‐effective alternative treatment of tense ascites in patients with cirrhosis. (HEPATOLOGY 1991;14:1025–1028.) Copyright © 1991 American Association for the Study of Liver Diseases DO - 10.1002/HEP.1840140613 UR - https://portalciencia.ull.es/documentos/5ea4b6022999526c8efa0f9f DP - Dialnet - Portal de la Investigación ER -