Estudio de la morfología y la función renal en niños diagnosticados de enuresis nocturna. Su relación con la sensibilidad o la resistencia a la desmopresina

  1. Carmen Luz Marrero Pérez
  2. Víctor Manuel García Nieto
  3. M.I. Luis Yanes
Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría ( AEP )

ISSN: 1695-4033

Year of publication: 2005

Volume: 63

Issue: 6

Pages: 475-479

Type: Article


In the last few years, there have been reports that children with nocturnal enuresis frequently have hypercalciuria.Likewise, children with desmopressin-resistant enuresis have recently been reported to have a higher renal concentration capacity than patients with desmopressinsensitive enuresis. Objectives To study renal function and urinary calcium excretion and to register familial history of enuresis and urolithiasis in a group of children with enuresis, whether responders or nonresponders to desmopressin, followed-up in our hospital. Material and methods A cohort of 60 patients (42 boys and 18 girls) who were referred to the hospital because of nocturnal enuresis. Results Hypercalciuria was detected in 26 children (43.3 %) and hypocitraturia in eight (13.3 %). The frequency of hyper-calciuria was higher in desmopressin-resistant patients than in desmopressin-sensitive patients, but this difference was not statistically significant. Sonographic renal morphological anomalies were detected in 11 children (18.3 %). No differences in renal handling of water were detected when the patients were distributed according to the grade of sensitivity to desmopressin. Conclusions In our cohort we found a high frequency of hypercalciuria in children with nocturnal enuresis. No differences were observed in maximal urinary osmolality among desmopressin-resistant and desmopressin-sensitive children.