TY  - JOUR
AU  - Mumuni, M.A.
AU  - Calister, U.E.
AU  - Aminu, N.
AU  - Franklin, K.C.
AU  - Oluseun, A.M.
AU  - Usman, M.
AU  - Abdulmumuni, B.
AU  - James, O.Y.
AU  - Ofokansi, K.C.
AU  - Anthony, A.A.
AU  - Ibezim, E.C.
AU  - Díaz, D.D.
T1  - Mucin-Grafted polyethylene glycol microparticles enable oral insulin delivery for improving diabetic treatment
LA  - eng
PY  - 2020
T2  - Applied Sciences (Switzerland)
SN  - 2076-3417
VL  - 10
IS  - 8
PB  - MDPI AG
AB  - In this study, different ratios of mucin-grafted polyethylene-glycol-based microparticles were prepared and evaluated both in vitro and in vivo as carriers for the oral delivery of insulin. Characterization measurements showed that the insulin-loaded microparticles display irregular porosity and shape. The encapsulation effciency and loading capacity of insulin were >82% and 18%, respectively. The release of insulin varied between 68% and 92% depending on the microparticle formulation. In particular, orally administered insulin-loaded microparticles resulted in a significant fall of blood glucose levels, as compared to insulin solution. Subcutaneous administration showed a faster, albeit not sustained, glucose fall within a short time as compared to the polymeric microparticle-based formulations. These results indicate the possible oral delivery of insulin using this combination of polymers.
DO  - 10.3390/APP10082649
UR  - https://portalciencia.ull.es/documentos/5ee23fb22999521d819e493c
DP  - Dialnet - Portal de la Investigación
ER  -