Dilute solutions of parahydroxybenzoates (parabens) as possible alternative for antimicrobial preservation in oral formulations for pediatrics

  1. Teigell-Pérez, N.
  2. Suárez-González, J. 1
  3. Soriano, M. 1
  4. Fariña, J.B. 1
  5. Santoveña, A. 1
  6. Vera, M. 1
  1. 1 Universidad de La Laguna
    info

    Universidad de La Laguna

    San Cristobal de La Laguna, España

    ROR https://ror.org/01r9z8p25

Revista:
International Journal of Pharmaceutics

ISSN: 0378-5173

Año de publicación: 2018

Volumen: 536

Número: 2

Páginas: 500-501

Tipo: Artículo

DOI: 10.1016/J.IJPHARM.2017.08.025 GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: International Journal of Pharmaceutics

Objetivos de desarrollo sostenible

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2015BIO27. Estudio sobre el desarrollo galénico, calidad y estabilidad de fórmulas magistrales y medicamentos adaptados en pediatría de interés en Canarias. FMPC.

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Referencias bibliográficas

  • EMA, reflection paper: formulations of choice for the paediatric population EMA/CHMP/PEG/194810/2005.
  • EMA, overview of comments received on the “reflection paper on the use of methyl- and propylparaben as excipients in human medicinal products for oral use” EMA/684369/2013.
  • EMA, reflection paper on the use of methyl- and propylparaben as excipients in human medicinal products for oral use EMA/CHMP/SWP/272921/2012. 22 October 2015.
  • European Pharmacopoeia 8th edition. 5.1.3. Efficacy of antimicrobial preservation 01/2011:50103.
  • Ghulam, (2007), Ann. Pharmacother., 41, pp. 857, 10.1345/aph.1H611
  • Han, (2006), J. Clin. Pharm. Ther., 31, pp. 167, 10.1111/j.1365-2710.2006.00720.x
  • Handbook of pharmaceutical excipients, Row, R.C., Sheskey, P.J., Quinn, M.E. (Eds.) 6th ed., PhP, London 2009.
  • Nahata, (2000), Ann. Pharmacother., 34, pp. 848, 10.1345/aph.19273
  • Spanish National Formulary, simple syrup FN/2003/EX/022.
  • Spanish National Formulary, preservative water FN/2003/EX/001.
  • Spanish National Formulary, concentrated solution of hydroxybenzoates FN/2003/EX/025.