Sex steroids and growth hormone interactions

  1. Leandro Francisco Fernández Pérez 1
  2. Mercedes de Mirecki Garrido 1
  3. Borja Guerra Hernández 1
  4. Mario Lorenzo Díaz González 2
  5. Juan Carlos Diaz Chico 1
  1. 1 IUIBS
  2. 2 Universidad de La Laguna
    info

    Universidad de La Laguna

    San Cristobal de La Laguna, España

    GRID grid.10041.34

Journal:
Endocrinología y nutrición: órgano de la Sociedad Española de Endocrinología y Nutrición

ISSN: 1575-0922

Year of publication: 2016

Volume: 63

Issue: 4

Pages: 171-180

Type: Article

Export: RIS
DOI: 10.1016/j.endonu.2015.11.004 DIALNET GOOGLE SCHOLAR

Metrics

Cited by

  • Scopus Cited by: 7 (31-10-2021)

JCR (Journal Impact Factor)

  • Year 2016
  • Journal Impact Factor: 1.106
  • Best Quartile: Q4
  • Area: NUTRITION & DIETETICS Quartile: Q4 Rank in area: 64/81 (Ranking edition: SCIE)
  • Area: ENDOCRINOLOGY & METABOLISM Quartile: Q4 Rank in area: 127/138 (Ranking edition: SCIE)

Abstract

GH and sex hormones are critical regulators of body growth and composition, somatic development, intermediate metabolism, and sexual dimorphism. Deficiencies in GH- or sex hormone-dependent signaling and the influence of sex hormones on GH biology may have a dramatic impact on liver physiology during somatic development and in adulthood. Effects of sex hormones on the liver may be direct, through hepatic receptors, or indirect by modulating endocrine, metabolic, and gender-differentiated functions of GH. Sex hormones can modulate GH actions by acting centrally, regulating pituitary GH secretion, and peripherally, by modulating GH signaling pathways. The endocrine and/or metabolic consequences of long-term exposure to sex hormone-related compounds and their influence on the GH-liver axis are largely unknown. A better understanding of these interactions in physiological and pathological states will contribute to preserve health and to improve clinical management of patients with growth, developmental, and metabolic disorders.