TY - GEN AU - Alonso-Fuentes, M.C. AU - Hernández, G. AU - Alonso, R. T1 - Líneas celulares adenohipofisarias αT3-1, LβT2, RC-4B/C y MtTW-10: Regulación y fisiología celular TI - Anterior pituitary cell lines αT3-1, LβT2, RC-4B/C and MtTW-10: Regulation and cellular physiology LA - spa PY - 2004 SP - 405 EP - 417 T2 - Endocrinologia y Nutricion SN - 1575-0922 VL - 51 IS - 7 PB - Ediciones Doyma, S.L. AB - The anterior pituitary is a well-structured organ with a clearly defined function, which offers the possibility of studying the mechanisms involved in organogenesis and the maintenance of specific cell functions. Due to the cellular diversity of this endocrine gland, obtaining highly purified primary cell cultures from this organ is difficult. Recently developed techniques based on targeted oncogenesis have enabled immortalized cell lines that maintain specific differentiated phenotypes to be obtained and constitute a valuable tool for studying their cell biology. These model systems have allowed detailed investigation into cellular and molecular mechanisms otherwise inaccessible in vivo or in complex primary pituitary cell cultures. Thus, gonadotroph cell lines such as αT3-1 and LβT2 are representative of discrete stages of development that express differentiated functions of the gonadotroph lineage. In addition to these experimental systems, there are others that show a cellular population as diverse as those observed in adult anterior pituitary glands, such as the RC-4B/C and MtTW-10 cell lines. In the present article we provide a brief description of each of the above-mentioned cell lines and review several aspects of their regulation by various factors. DO - 10.1016/S1575-0922(04)74637-9 UR - https://portalciencia.ull.es/documentos/608ab6cc1c42383529deb2d3 DP - Dialnet - Portal de la Investigación ER -