DHA and Its Elaborated Modulation of Antioxidant Defenses of the Brain: Implications in Aging and AD Neurodegeneration

  1. Marín, Raquel 1
  2. Díaz, Mario 1
  3. Mesa-Herrera, Fátima 1
  1. 1 Universidad de La Laguna
    info

    Universidad de La Laguna

    San Cristobal de La Laguna, España

    GRID grid.10041.34

Journal:
Antioxidants

ISSN: 2076-3921

Year of publication: 2021

Volume: 10

Issue: 6

Pages: 907

Type: Article

Export: RIS
DOI: 10.3390/antiox10060907 GOOGLE SCHOLAR
Author's full text: lockOpen access editor

Metrics

JCR (Journal Impact Factor)

(Indicator corresponding to the last year available on this portal, year 2020)
  • Year 2020
  • Journal Impact Factor: 6.312
  • Best Quartile: Q1
  • Area: BIOCHEMISTRY & MOLECULAR BIOLOGY Quartile: Q1 Rank in area: 60/297 (Ranking edition: SCIE)
  • Area: FOOD SCIENCE & TECHNOLOGY Quartile: Q1 Rank in area: 11/144 (Ranking edition: SCIE)
  • Area: CHEMISTRY, MEDICINAL Quartile: Q1 Rank in area: 6/63 (Ranking edition: SCIE)

SCImago Journal Rank

(Indicator corresponding to the last year available on this portal, year 2020)
  • Year 2020
  • SJR Journal Impact: 1.067
  • Best Quartile: Q2
  • Area: Biochemistry Quartile: Q2 Rank in area: 136/438
  • Area: Clinical Biochemistry Quartile: Q2 Rank in area: 31/121
  • Area: Cell Biology Quartile: Q2 Rank in area: 142/289
  • Area: Molecular Biology Quartile: Q2 Rank in area: 187/402
  • Area: Physiology Quartile: Q2 Rank in area: 60/178

CiteScore

(Indicator corresponding to the last year available on this portal, year 2020)
  • Year 2020
  • CiteScore of the Journal : 4.3
  • Area: Physiology Percentile: 52
  • Area: Clinical Biochemistry Percentile: 50
  • Area: Biochemistry Percentile: 50
  • Area: Molecular Biology Percentile: 41
  • Area: Cell Biology Percentile: 40

Journal Citation Indicator (JCI)

(Indicator corresponding to the last year available on this portal, year 2020)
  • Year 2020
  • Journal Citation Indicator (JCI): 1.24
  • Best Quartile: Q1
  • Area: CHEMISTRY, MEDICINAL Quartile: Q1 Rank in area: 16/71
  • Area: FOOD SCIENCE & TECHNOLOGY Quartile: Q1 Rank in area: 24/163
  • Area: BIOCHEMISTRY & MOLECULAR BIOLOGY Quartile: Q1 Rank in area: 54/311

Abstract

DHA (docosahexaenoic acid) is perhaps the most pleiotropic molecule in nerve cell biology. This long-chain highly unsaturated fatty acid has evolved to accomplish essential functions ranging from structural components allowing fast events in nerve cell membrane physiology to regulation of neurogenesis and synaptic function. Strikingly, the plethora of DHA effects has to take place within the hostile pro-oxidant environment of the brain parenchyma, which might suggest a molecular suicide. In order to circumvent this paradox, different molecular strategies have evolved during the evolution of brain cells to preserve DHA and to minimize the deleterious effects of its oxidation. In this context, DHA has emerged as a member of the “indirect antioxidants” family, the redox effects of which are not due to direct redox interactions with reactive species, but to modulation of gene expression within thioredoxin and glutathione antioxidant systems and related pathways. Weakening or deregulation of these self-protecting defenses orchestrated by DHA is associated with normal aging but also, more worryingly, with the development of neurodegenerative diseases. In the present review, we elaborate on the essential functions of DHA in the brain, including its role as indirect antioxidant, the selenium connection for proper antioxidant function and their changes during normal aging and in Alzheimer’s disease.

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