TY  - JOUR
AU  - Franceschy, C.
AU  - Espinoza, C.
AU  - Padrón, J.M.
AU  - Landa-Cadena, G.
AU  - Norte, M.
AU  - Fernández, J.J.
AU  - Shnyreva, A.
AU  - Trigos, Á.
T1  - Antiproliferative potential of 3β,5α,6β,7α-tetrahydroxyergosta-8(14),22-diene produced by Acremonium persicinum isolated from an alkaline crater lake in Puebla, Mexico
LA  - eng
PY  - 2021
SP  - 2895
EP  - 2898
T2  - Natural Product Research
SN  - 1478-6427
VL  - 35
IS  - 17
PB  - Taylor and Francis Ltd.
AB  - The sterol 3β,5α,6β,7α-tetrahydroxyergosta-8(14),22-diene was obtained from bio-guided fractioning of the chloroform extract of 50 L of liquid culture of Acremonium persicinum. This fungal strain was selected because of its anti-proliferative activity against solid human tumour cell lines (GI50 ≤ 50 μg/mL) in a bio-prospective study of fungi isolated from plant material, sediment and water samples obtained from alkaline lakes Alchichica and Atexcac in Puebla, Mexico. This compound showed GI50 (μM) values of: 16, 24, 18, 15 and 12 against tumour cell lines A-549, HBL-100, HeLa, T-47D and WiDr respectively. GI50 effects against tumour lines T-47D and WiDr were found to be greater than the clinically used drugs Etoposide and Cisplatin. Because of this, the results obtained support the pharmacological importance of the microorganisms that develop in these ecosystems and strengthen the non-invasive bio-prospection studies that our work group has developed in recent years.
DO  - 10.1080/14786419.2019.1669032
UR  - https://portalciencia.ull.es/documentos/60e6a2414edb8e25f92ce258
DP  - Dialnet - Portal de la Investigación
ER  -