A micro-extrusion 3D printing platform for fabrication of orodispersible printlets for pediatric use

  1. Díaz-Torres, Eduardo 1
  2. Santovena-Estevez, Ana 1
  3. Farina, Jose B. 1
  1. 1 Universidad de La Laguna
    info

    Universidad de La Laguna

    San Cristobal de La Laguna, España

    GRID grid.10041.34

Journal:
International Journal of Pharmaceutics

ISSN: 0378-5173

Year of publication: 2021

Type: Article

Export: RIS

Metrics

JCR (Journal Impact Factor)

(Indicator corresponding to the last year available on this portal, year 2020)
  • Year 2020
  • Journal Impact Factor: 5.875
  • Best Quartile: Q1
  • Area: PHARMACOLOGY & PHARMACY Quartile: Q1 Rank in area: 37/275 (Ranking edition: SCIE)

SCImago Journal Rank

(Indicator corresponding to the last year available on this portal, year 2020)
  • Year 2020
  • SJR Journal Impact: 1.153
  • Best Quartile: Q1
  • Area: Pharmaceutical Science Quartile: Q1 Rank in area: 13/182

CiteScore

(Indicator corresponding to the last year available on this portal, year 2020)
  • Year 2020
  • CiteScore of the Journal : 8.2
  • Area: Pharmaceutical Science Percentile: 92

Journal Citation Indicator (JCI)

(Indicator corresponding to the last year available on this portal, year 2020)
  • Year 2020
  • Journal Citation Indicator (JCI): 1.66
  • Best Quartile: Q1
  • Area: PHARMACOLOGY & PHARMACY Quartile: Q1 Rank in area: 19/356

Abstract

3D printed pharmaceuticals offers the potential to manufacture personalized medicines for patients. Such technology is of particular benefit to pediatric populations from the offer of increased patient compliance and dose flexibility. With a bench-to-patient approach, this study established and optimized the critical parameters of the semi-solid micro-extrusion 3D printing process to guarantee the quality attributes of the final dosage form. Pediatrics orodispersible printlets of hydrochlorothiazide were manufactured through the modification of printing parameters, as well as printing surfaces materials. The printlets were characterized and the dimensions were measured using a digital caliper and computer vision algorithm. This study identified that the printing surface material and the first printing layer are critical parameters for high-resolution printlets. Following the optimization of 3D printing parameters, high quality orodispersible printlets loaded with hydrochlorothiazide – specifically tailored for pediatric patient’s dosage forms – were obtained (4.62 mm ×1.90 mm). Mass and content uniformity assays demonstrated that the printlets satisfied the requirements for orodispersible printlets set by the European Pharmacopoeia. As such, in order to transition from laboratory research towards the treatment of patients, distinguishing accurate 3D printing parameters is necessary for the manufacture of medicines with key quality attributes that follow Pharmacopoeia requirements.