TY  - JOUR
AU  - Gómez, Ricardo
AU  - Maglio, Laura E.
AU  - Gonzalez-Hernandez, Alberto J.
AU  - Rivero-Pérez, Belinda
AU  - Bartolomé-Martín, David
AU  - Giraldez, Teresa
KW  - Multidisciplinary
T1  - NMDA receptor–BK channel coupling regulates synaptic plasticity in the barrel cortex
LA  - eng
PY  - 2021
SP  - e2107026118
T2  - Proceedings of the National Academy of Sciences
SN  - 0027-8424
VL  - 118
IS  - 35
AB  - Postsynaptic N-methyl-D-aspartate receptors (NMDARs) are crucial mediators of synaptic plasticity due to their ability to act as coincidence detectors of presynaptic and postsynaptic neuronal activity. However, NMDARs exist within the molecular context of a variety of postsynaptic signaling proteins, which can fine-tune their function. Here, we describe a form of NMDAR suppression by large-conductance Ca2+- and voltage-gated K+ (BK) channels in the basal dendrites of a subset of barrel cortex layer 5 pyramidal neurons. We show that NMDAR activation increases intracellular Ca2+ in the vicinity of BK channels, thus activating K+ efflux and strong negative feedback inhibition. We further show that neurons exhibiting such NMDAR–BK coupling serve as high-pass filters for incoming synaptic inputs, precluding the induction of spike timing–dependent plasticity. Together, these data suggest that NMDAR-localized BK channels regulate synaptic integration and provide input-specific synaptic diversity to a thalamocortical circuit.
DO  - 10.1073/PNAS.2107026118
UR  - https://portalciencia.ull.es/documentos/61371e3815cff5474de99f6b
DP  - Dialnet - Portal de la Investigación
ER  -