Effects of amp-activated kinase modulators on intracellular ca2+ signalling and c. Elegans lifespan

  1. Arias del Val, Jessica
Dirigida por:
  1. Javier Álvarez Martín Director/a
  2. Mayte Montero Director/a
  3. Rosalba I. Fonteriz García Director/a

Universidad de defensa: Universidad de Valladolid

Fecha de defensa: 27 de noviembre de 2018

Tribunal:
  1. María Teresa Alonso Alonso Presidente/a
  2. Ana Isabel de Cáceres Bustos Secretario/a
  3. Ricardo Borges Jurado Vocal

Tipo: Tesis

Resumen

AMPK is a key energy homeostasis regulator that coordinates metabolic pathways by balancing the supply of nutrients with energy demand. Current evidence supports the idea that anabolic signalling accelerates aging, while a decrease in nutrient signalling pathways extends longevity. In this way, a pharmacological intervention that mimics a limited availability of nutrients or activates catabolic pathways could extend longevity. Likewise, it is believed that the positive regulation of AMPK would favor a healthy aging. As the concepts of energy balance and nutrient-sensitive pathways are considered nowadays key determinants of lifespan, and Ca2+ signalling is tightly related to both of them, the main goal of this thesis is to investigate the relationship between the activity of the AMPK signalling pathway, intracellular Ca2+ signalling and aging in C. elegans, using AMPK modulating compounds and their analogs.