TY  - JOUR
AU  - Alquézar-Arbé, A.
AU  - Miró, Ò.
AU  - Castillo, J.G.D.
AU  - Jiménez, S.
AU  - Llorens, P.
AU  - Martín, A.
AU  - Martín-Sánchez, F.J.
AU  - García-Lamberechts, E.J.
AU  - Piñera, P.
AU  - Jacob, J.
AU  - Porrino, J.M.M.
AU  - Jiménez, B.
AU  - Río, R.D.
AU  - García, C.P.
AU  - Aznar, J.V.B.
AU  - Ponce, M.C.
AU  - Fernández, E.D.
AU  - Tost, J.
AU  - Mojarro, E.M.
AU  - García, A.H.
AU  - Quirós, A.M.
AU  - Noceda, J.
AU  - Cano, M.J.C.
AU  - Almela, A.F.D.S.
AU  - Bayarri, M.J.F.
AU  - Tejera, M.G.
AU  - Rodriguez, A.D.
AU  - Burillo-Putze, G.
KW  - acute coronary syndrome
KW  - clinical characteristics
KW  - COVID-19
KW  - incidence
KW  - outcome
KW  - risk factors
KW  - SARS-Cov-2
T1  - Incidence, Clinical Characteristics, Risk Factors and Outcomes of Acute Coronary Syndrome in Patients With COVID-19: Results of the UMC-19-S1010
LA  - eng
PY  - 2022
SP  - 443
EP  - 454
T2  - Journal of Emergency Medicine
SN  - 0736-4679
VL  - 62
IS  - 4
PB  - Elsevier Inc.
AB  - Background: There is a lack of knowledge about the real incidence of acute coronary syndrome (ACS) in patients with COVID-19, their clinical characteristics, and their prognoses. Objective: We investigated the incidence, clinical characteristics, risk factors, and outcomes of ACS in patients with COVID-19 in the emergency department. Methods: We retrospectively reviewed all COVID-19 patients diagnosed with ACS in 62 Spanish emergency departments between March and April 2020 (the first wave of COVID-19). We formed 2 control groups: COVID-19 patients without ACS (control A) and non–COVID-19 patients with ACS (control B). Unadjusted comparisons between cases and control subjects were performed regarding 58 characteristics and outcomes. Results: We identified 110 patients with ACS in 74,814 patients with COVID-19 attending the ED (1.48% [95% confidence interval {CI} 1.21–1.78%]). This incidence was lower than that observed in non–COVID-19 patients (3.64% [95% CI 3.54–3.74%]; odds ratio [OR] 0.40 [95% CI 0.33–0.49]). The clinical characteristics of patients with COVID-19 associated with a higher risk of presenting ACS were: previous coronary artery disease, age ≥60 years, hypertension, chest pain, raised troponin, and hypoxemia. The need for hospitalization and admission to intensive care and in-hospital mortality were higher in cases than in control group A (adjusted OR [aOR] 6.36 [95% CI 1.84–22.1], aOR 4.63 [95% CI 1.88–11.4], and aOR 2.46 [95% CI 1.15–5.25]). When comparing cases with control group B, the aOR of admission to intensive care was 0.41 (95% CI 0.21–0.80), while the aOR for in-hospital mortality was 5.94 (95% CI 2.84–12.4). Conclusions: The incidence of ACS in patients with COVID-19 attending the emergency department was low, around 1.48%, but could be increased in some circumstances. Patients with COVID-19 with ACS had a worse prognosis than control subjects with higher in-hospital mortality.
DO  - 10.1016/J.JEMERMED.2021.10.046
UR  - https://portalciencia.ull.es/documentos/61ff08d413638e1cfc2794aa
DP  - Dialnet - Portal de la Investigación
ER  -