Letter to the FDA Proposing Major Changes in the US Clozapine Package Insert Supported by Clozapine Experts Worldwide. Part II: A review of fatal outcomes in US Pharmacovigilance data and proposed changes

  1. de Leon, Jose
  2. Baldessarini, Ross J.
  3. Balon, Richard 25
  4. Bilbily, John 3
  5. Caroff, Stanley N.
  6. Citrome, Leslie 1
  7. Correll, Christoph U.
  8. Cotes, Robert O. 5
  9. Davis, John M. 28
  10. DeLisi, Lynn E. 19
  11. Faden, Justin 11
  12. Freudenreich, Oliver 15
  13. Goldsmith, David R. 5
  14. Gurrera, Ronald
  15. Josiassen, Richard C. 10
  16. Kane, John M.
  17. Kelly, Deanna L. 24
  18. Keshavan, Matcheri S. 14
  19. Laitman, Robert S. 21
  20. Lam, Y. W. Francis 17
  21. Leung, Jonathan G. 18
  22. Love, Raymond C. 7
  23. McCollum, Betsy 6
  24. McGrane, Ian R. 4
  25. Meyer, Jonathan M. 13
  26. Nasrallah, Henry A. 20
  27. Nucifora, Frederick C. 9
  28. Rothschild, Anthony J. 22
  29. Rubio, Jose M.
  30. Sajatovic, Martha 8
  31. Sarpal, Deepak K. 23
  32. Schoretsanitis, Georgios
  33. Shad, Mujeeb 26
  34. Shelton, Charles
  35. Sher, Leo 27
  36. Singh, Balwinder 16
  37. Surya, Sandarsh 29
  38. Zarzar, Theodore R. 12
  39. Sanz, Emilio J.
  40. De las Cuevas, Carlos 2
  41. Show all authors +
  1. 1 New York Medical College, Department of Psychiatry and Behavioral Sciences, Valhalla, NY
  2. 2 Department of Internal Medicine, Dermatology and Psychiatry, School of Medicine, and Instituto Universitario de Neurociencia (IUNE), University of La Laguna, Canary Islands, Spain.
  3. 3 Department of Psychiatry, Washington University in St. Louis, St. Louis, MO
  4. 4 Department of Pharmacy Practice, University of Montana, Missoula, MT
  5. 5 Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA
  6. 6 Eastern State Hospital, Lexington, KY
  7. 7 Department of Practice, Sciences, and Health Outcomes Research, University of Maryland School of Pharmacy, Baltimore, MD
  8. 8 Department of Psychiatry and of Neurology, Case Western Reserve University School of Medicine, University Hospitals Cleveland Medical Center, Cleveland, OH
  9. 9 Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD
  10. 10 Translational Neuroscience LLC, Conshohocken, PA
  11. 11 Department of Psychiatry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA
  12. 12 Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC
  13. 13 Department of Psychiatry, University of California, San Diego, CA
  14. 14 Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA
  15. 15 Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA
  16. 16 Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN
  17. 17 Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX
  18. 18 Department of Pharmacy, Mayo Clinic, Rochester, MN
  19. 19 Department of Psychiatry, Cambridge Health Alliance, Harvard Medical School, Cambridge, MA
  20. 20 Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, OH
  21. 21 Bronx Westchester Medical Group, Mount Kisco, NY
  22. 22 Department of Psychiatry, University of Massachusetts Chan Medical School and UMass Memorial HealthCare, Worcester, MA
  23. 23 Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA
  24. 24 Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD
  25. 25 Departments of Psychiatry and Behavioral Neurosciences and Anesthesiology, Wayne State University, Detroit, MI
  26. 26 Department of Psychiatry, University of Nevada, Las Vegas, NV
  27. 27 Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY
  28. 28 Department of Psychiatry, University of Illinois at Chicago, Chicago, IL
  29. 29 Department of Psychiatry and Health Behavior, Augusta University, Augusta, GA
Show affiliations +
Journal:
Journal of Clinical Psychopharmacology

ISSN: 1533-712X,  0271-0749

Year of publication: 2025

Type: Article

DOI: 10.1097/JCP.0000000000001990 GOOGLE SCHOLAR lock_openOpen access editor

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Bibliographic References

  • (2016), Clin Ther, 38, pp. 2509, 10.1016/j.clinthera.2016.11.008
  • (2007), Curr Drug Saf, 2, pp. 177, 10.2174/157488607781668855
  • (2020), Psychother Psychosom, 89, pp. 200, 10.1159/000507638
  • (2025), J Clin Psychopharmacol, 45
  • (2007), Hist Psychiatry, 18, pp. 39, 10.1177/0957154X07070335
  • (1975), Lancet, 2, pp. 611
  • (1977), Eur J Clin Pharmacol, 11, pp. 199, 10.1007/BF00606410
  • (2024), Schizophr Res, 268, pp. 7, 10.1016/j.schres.2023.08.019
  • (2024), Schizophr Res, 268, pp. 9, 10.1016/j.schres.2024.01.035
  • (1998), Arch Gen Psychiatry, 45, pp. 789
  • (1999), Lancet, 354, pp. 1841, 10.1016/S0140-6736(99)10385-4
  • (2001), N Engl J Med, 345, pp. 224, 10.1056/NEJM200107193450317
  • (2024), Schizophr Res, 268, pp. 165
  • (2024), Schizophr Res, 268, pp. 175, 10.1016/j.schres.2023.11.010
  • (2023), J Clin Psychopharmacol, 43, pp. 239, 10.1097/JCP.0000000000001678
  • (2008), J Clin Psychiatry, 69, pp. 759, 10.4088/JCP.v69n0509
  • (2024), Br J Psychiatry, 225, pp. 572, 10.1192/bjp.2024.140
  • (2024), Am J Psychiatry, 181, pp. 879, 10.1176/appi.ajp.20230744
  • (2005), J Clin Psychiatry, 66, pp. 530, 10.4088/JCP.v66n0417
  • (2011), J Clin Psychopharmacol, 31, pp. 263, 10.1097/JCP.0b013e318218f3e4
  • (2013), Stat Methods Med Res, 22, pp. 57, 10.1177/0962280211403604
  • (2016), J Clin Psychopharmacol, 36, pp. 198, 10.1097/JCP.0000000000000490
  • (2022), Br J Clin Pharmacol, 88, pp. 5434, 10.1111/bcp.15522
  • (2006), Drug Saf, 29, pp. 385, 10.2165/00002018-200629050-00003
  • (2009), Drug Saf, 32, pp. 19, 10.2165/00002018-200932010-00002
  • (2020), Healthcare (Basel), 10, pp. 1015
  • (2014), Rev Esc Enferm USP, 48, pp. 739, 10.1590/S0080-623420140000400023
  • (2024), Patient Prefer Adherence, 18, pp. 2261, 10.2147/PPA.S495254
  • (2017), Acta Psychiatr Scand, 136, pp. 37, 10.1111/acps.12742
  • (2021), Acta Psychiatr Scand, 143, pp. 339, 10.1111/acps.13280
  • (2022), Lancet Psychiatry, 9, pp. 537, 10.1016/S2215-0366(22)00154-7
  • (2007), Biol Psychiatry, 62, pp. 345, 10.1016/j.biopsych.2006.09.023
  • (2010), Cochrane Database Syst Rev, 11, pp. CD006633
  • (2010), Seizure, 19, pp. 69, 10.1016/j.seizure.2009.11.005
  • (2023), Eur Neuropsychopharmacol, 68, pp. 33, 10.1016/j.euroneuro.2022.12.010
  • (1995), J Clin Psychiatry, 56, pp. 418
  • (1994), Biol Psychiatry, 36, pp. 759, 10.1016/0006-3223(94)90087-6
  • (2011), Brain Res, 1421, pp. 66, 10.1016/j.brainres.2011.08.073
  • (2023), Toxicol Sci, 196, pp. 126, 10.1093/toxsci/kfad087
  • (1985), Acta Psychiatr Scand, 71, pp. 176, 10.1111/j.1600-0447.1985.tb01268.x
  • (1989), Psychopharmacology (Berl), 99, pp. S97
  • (1994), Neurology, 44, pp. 2247, 10.1212/WNL.44.12.2247
  • (2023), PLoS One, 18, pp. e0287122, 10.1371/journal.pone.0287122
  • (1978), Am J Psychiatry, 135, pp. 99, 10.1176/ajp.135.1.99
  • (2022), Pharmaceuticals (Basel), 15, pp. 817, 10.3390/ph15070817
  • (2018), Prim Care Companion CNS Disord, 20, pp. 17l02151
  • (2019), Expert Rev Clin Pharmacol, 12, pp. 603, 10.1080/17512433.2019.1617695
  • (1991), Schizophr Bull, 17, pp. 247, 10.1093/schbul/17.2.247
  • (1988), Pharmacopsychiatry, 21, pp. 306, 10.1055/s-2007-1016987
  • (1989), Psychopharmacology (Berl), 99, pp. S101
  • (1991), New Eng J Med, 325, pp. 518, 10.1056/NEJM199108153250716
  • (1994), Am J Psychiatry, 151, pp. 780, 10.1176/ajp.151.5.780a
  • (1997), J Clin Psychiatry, 58, pp. 547, 10.4088/JCP.v58n1206a
  • (2006), Res Dev Disabil, 27, pp. 309, 10.1016/j.ridd.2005.05.002
  • (2022), Rev Psiquiatr Salud Ment (English Ed), 15, pp. 238
  • (2022), Expert Rev Clin Pharmacol, 15, pp. 65, 10.1080/17512433.2022.2032659
  • (2023), Psychiatry Investig, 20, pp. 183, 10.30773/pi.2022.0293
  • (2024), J Clin Psychopharmacol, 44, pp. 212, 10.1097/JCP.0000000000001843
  • (2024), Schizophr Res, 268, pp. 312, 10.1016/j.schres.2023.08.002
  • (1980), Ugeskr Laeger, 142, pp. 170
  • (1993), Current Problems in Pharmacovigilance, 19, pp. 9
  • (2001), BMJ, 322, pp. 1207, 10.1136/bmj.322.7296.1207
  • (2000), Lancet, 355, pp. 841, 10.1016/S0140-6736(05)72451-X
  • (2022), Psychiatr Danub, 34, pp. 411, 10.24869/psyd.2022.411
  • (1972), Pharmacopsychiatry, 5, pp. 155, 10.1055/s-0028-1094343
  • (1989), Psychopharmacology (Berl), 99Suppl, pp. S73
  • (1989), Psychopharmacology (Berl), pp. S80
  • (2019), Schizophr Res, 211, pp. 1, 10.1016/j.schres.2019.07.040
  • (2020), Expert Rev Clin Pharmacol, 13, pp. 875, 10.1080/17512433.2020.1787831
  • (2021), J Psychopharmacol, 35, pp. 1062, 10.1177/02698811211021587
  • (2022), Eur Neuropsychopharmacol, 60, pp. 25, 10.1016/j.euroneuro.2022.04.009
  • (2022), Expert Opin Drug Metab Toxicol, 18, pp. 715, 10.1080/17425255.2022.2160318
  • (2024), Schizophr Res, 268, pp. 118, 10.1016/j.schres.2023.10.027
  • (2022), Pharmacopsychiatry, 55, pp. 73, 10.1055/a-1625-6388
  • (2022), Rev Psiquiatr Salud Ment (Engl Ed), 15, pp. 281, 10.1016/j.rpsm.2021.10.003
  • (2022), Neuropsychopharmacol Hung, 24, pp. 29
  • (2022), Neuropsychopharmacol Hung, 24, pp. 153
  • (2023), Pharmacotherapy, 43, pp. 1364, 10.1002/phar.2887
  • (2024), Schizophr Res, 268, pp. 98, 10.1016/j.schres.2023.06.003
  • (2023), Schizophrenia (Heidelb), 9, pp. 82, 10.1038/s41537-023-00412-6
  • (2024), Br J Psychiatry, 225, pp. 492, 10.1192/bjp.2024.113
  • (2024), Schizophr Res, 268, pp. 88, 10.1016/j.schres.2023.09.019
  • (2024), Schizophr Res, 268, pp. 131
  • (2024), Schizophr Res, 268, pp. 107, 10.1016/j.schres.2023.09.029
  • (2023), Schizophr Res, 261, pp. 203, 10.1016/j.schres.2023.09.031
  • (2014), Int J Cardiol, 176, pp. 315, 10.1016/j.ijcard.2014.07.103
  • (2016), Curr Psychiatry Rep, 18, pp. 68, 10.1007/s11920-016-0704-3
  • (2020), Aust NZ J Psychiatry, 54, pp. 467, 10.1177/0004867419898760
  • (2022), Acta Psychiatr Scand, 145, pp. 442, 10.1111/acps.13398
  • (2011), BMJ Case Rep, 2011, pp. bcr1020115030
  • (2019), Expert Rev Clin Pharmacol, 12, pp. 219, 10.1080/17512433.2019.1577134
  • (2022), Expert Opin Drug Metab Toxicol, 18, pp. 541, 10.1080/17425255.2022.2122813
  • (2023), Expert Opin Drug Metab Toxicol, 19, pp. 57, 10.1080/17425255.2023.2192401
  • (2024), Schizophr Res, 268, pp. 285, 10.1016/j.schres.2023.07.004
  • (2023), Psychogeriatrics, 23, pp. 963, 10.1111/psyg.13017
  • (2010), Circulation, 122, pp. 1426, 10.1161/CIRCULATIONAHA.109.894725
  • (2014), Expert Opin Drug Metab Toxicol, 10, pp. 721, 10.1517/17425255.2014.885504
  • (2010), Pharmacol Rev, 62, pp. 760, 10.1124/pr.110.003723
  • (2014), Mol Pharmacol, 85, pp. 769, 10.1124/mol.114.091835
  • (2023), Naunyn Schmiedebergs Arch Pharmacol, 396, pp. 161, 10.1007/s00210-022-02314-3
  • (2021), Clin Pharmacol Ther, 109, pp. 1606, 10.1002/cpt.2133
  • (2011), Hum Psychopharmacol, 26, pp. 397, 10.1002/hup.1221
  • (2020), Kaohsiung J Med Sci, 36, pp. 1030, 10.1002/kjm2.12280
  • (2022), J Clin Psychopharmacol, 42, pp. 536, 10.1097/JCP.0000000000001605
  • (2022), Prim Care Companion CNS Disord, 24, pp. 21m02915
  • (2024), Schizophr Res, 268, pp. 145, 10.1016/j.schres.2023.09.032
  • (2024), Schizophr Res, 264, pp. 370, 10.1016/j.schres.2024.01.003
  • (2019), Lancet, 394, pp. 939, 10.1016/S0140-6736(19)31135-3
  • (2014), Eur Heart J, 35, pp. 1306, 10.1093/eurheartj/ehu100
  • (2024), Br J Clin Pharmacol
  • (2003), Prog Neuropsychopharmacol Biol Psychiatry, 27, pp. 1059, 10.1016/S0278-5846(03)00148-9
  • (2018), Schizophr Res, 192, pp. 50, 10.1016/j.schres.2017.03.045
  • (2020), Psychother Psychosom, 89, pp. 255, 10.1159/000506355
  • (2022), Rev Psiquiatr Salud Ment (Engl Ed), 15, pp. 290, 10.1016/j.rpsm.2022.06.001
  • (2022), Pharmacopsychiatry, 55, pp. 48, 10.1055/a-1562-2521
  • (2024), J Clin Psychopharmacol, 44, pp. 201, 10.1097/JCP.0000000000001828
  • (2004), J Clin Psychiatry, 65, pp. 1144
  • (2020), J Psychiatry Neurosci, 45, pp. 222, 10.1503/jpn.200061
  • (2024), Expert Opin Drug Metab Toxicol, 20, pp. 857, 10.1080/17425255.2024.2373111
  • (2024), JAMA Psychiatry, 81, pp. 967, 10.1001/jamapsychiatry.2024.1441
  • (2024), Lancet Psychiatry, 11, pp. 443, 10.1016/S2215-0366(24)00097-X
  • (2021), Expert Rev Clin Pharmacol, 14, pp. 145, 10.1080/17512433.2021.1877135
  • (2016), J Clin Psychopharmacol, 36, pp. 174, 10.1097/JCP.0000000000000458
  • (2018), Br J Psychiatry, 214, pp. 1
  • (2020), Acta Psychiatr Scand, 142, pp. 78, 10.1111/acps.13142
  • (2020), Acta Psychiatr Scand, 142, pp. 66, 10.1111/acps.13184
  • (2022), World Psychiatry, 21, pp. 248, 10.1002/wps.20994
  • (2019), Acta Psychiatr Scand, 140, pp. 227, 10.1111/acps.13066
  • (2023), Front Pharmacol, 14, pp. 1260915, 10.3389/fphar.2023.1260915
  • (2015), Am J Psychiatry, 172, pp. 776, 10.1176/appi.ajp.2015.14091100
  • (2024), Lancet Psychiatry, 11, pp. 796, 10.1016/S2215-0366(24)00223-2
  • (2024), eClinicalMedicine, 77, pp. 102867, 10.1016/j.eclinm.2024.102867
  • (2022), CNS Drugs, 36, pp. 659, 10.1007/s40263-022-00932-2
  • (2022), Acta Psychiatr Scand, 145, pp. 423, 10.1111/acps.13406
  • (2018), Ther Adv Drug Saf, 9, pp. 237, 10.1177/2042098618756261
  • (2023), World Psychiatry, 22, pp. 86, 10.1002/wps.21068
  • (2009), Lancet, 374, pp. 620, 10.1016/S0140-6736(09)60742-X
  • (2023), Psychol Med, 53, pp. 5528, 10.1017/S0033291722002732
  • (2010), J Clin Psychiatry, 71, pp. 304, 10.4088/JCP.08m04718yel
  • (2019), Psychiatry Q, 90, pp. 351, 10.1007/s11126-018-9621-4
  • (2021), Acta Psychiatr Scand, 143, pp. 216, 10.1111/acps.13267
  • (2013), Schizophr Res, 150, pp. 274, 10.1016/j.schres.2013.07.043
  • (2020), World Psychiatry, 19, pp. 61, 10.1002/wps.20699
  • (2002), Schizophr Bull, 48, pp. 166
  • (2015), J Clin Psychiatry, 76, pp. e111, 10.4088/JCP.14m08996
  • (2010), Schizophr Res, 119, pp. 160, 10.1016/j.schres.2009.12.005
  • (2021), Front Genet, 12, pp. 607690, 10.3389/fgene.2021.607690
  • (2005), Schizophr Res, 76, pp. 135, 10.1016/j.schres.2005.02.010
  • (2005), Br J Psychiatry, 186, pp. 215, 10.1192/bjp.186.3.215
  • (2012), Hum Genet, 131, pp. 877, 10.1007/s00439-011-1122-6
  • (2023), Am J Psychiatry, 180, pp. 815, 10.1176/appi.ajp.20220660
  • (2020), Eur Neuropsychopharmacol, 32, pp. 56, 10.1016/j.euroneuro.2019.12.118
  • (2024), Eur Neuropsychopharmacol, 88, pp. 6, 10.1016/j.euroneuro.2024.07.009
  • (2016), Br J Clin Pharmacol, 82, pp. 624, 10.1111/bcp.12985
  • (2019), BMC Psychiatry, 19, pp. 189, 10.1186/s12888-019-2177-5
  • (2017), J Psychopharmacol, 31, pp. 1544, 10.1177/0269881117714047
  • (2015), Eur Heart J, 36, pp. 984, 10.1093/eurheartj/ehu263
  • (2014), CNS Drugs, 28, pp. 963, 10.1007/s40263-014-0176-0
  • (2017), Ther Clin Risk Manag, 13, pp. 757, 10.2147/TCRM.S117321
  • (2020), Lancet Psychiatry, 7, pp. 64, 10.1016/S2215-0366(19)30416-X
  • (2024), J Affect Disord, 356, pp. 647, 10.1016/j.jad.2024.04.080
  • (2000), Lancet, 355, pp. 1155, 10.1016/S0140-6736(00)02066-3
  • (2008), Psychiatry Clin Neurosci, 62, pp. 3, 10.1111/j.1440-1819.2007.01773.x
  • (2017), Clin Schizophr Relat Psychoses
  • (2022), Asian J Psychiatr, 73, pp. 103105, 10.1016/j.ajp.2022.103105
  • (2024), Expert Opin Drug Saf, 27, pp. 1
  • (2019), J Community Hosp Intern Med Perspect, 9, pp. 300, 10.1080/20009666.2019.1627848
  • (2014), J Clin Psychopharmacol, 34, pp. 385, 10.1097/JCP.0000000000000124
  • (2022), Clin Case Rep, 10, pp. e05497, 10.1002/ccr3.5497
  • (2020), Int J Biol Macromol, 154, pp. 142, 10.1016/j.ijbiomac.2020.03.119
  • (2003), Arch Gen Psychiatry, 60, pp. 82, 10.1001/archpsyc.60.1.82
  • (2017), Am J Psychiatry, 174, pp. 990, 10.1176/appi.ajp.2017.16091097
  • (2018), Schizophr Res, 197, pp. 274, 10.1016/j.schres.2017.12.010
  • (2021), Schizophr Bull, 47, pp. 23, 10.1093/schbul/sbaa111
  • (2024), Schizophr Res, 268, pp. 150, 10.1016/j.schres.2023.07.014
  • (2003), CNS Drugs, 17, pp. 273, 10.2165/00023210-200317040-00004
  • (2005), Schizophr Res, 73, pp. 139, 10.1016/j.schres.2004.05.015
  • (2021), J Psychopharmacol, 35, pp. 1074, 10.1177/02698811211029738
  • (2023), Eur Neuropsychopharmacol, 69, pp. 4, 10.1016/j.euroneuro.2022.12.011
  • (2022), Depress Anxiety, 39, pp. 100, 10.1002/da.23222
  • (2023), J Clin Psychiatry, 84, pp. 22m14587
  • (2024), Schizophr Res, 268, pp. 161, 10.1016/j.schres.2023.08.029
  • (2012), Bipolar Disord, 14, pp. 863, 10.1111/bdi.12018
  • (2015), Bipolar Disord, 17, pp. 235, 10.1111/bdi.12272
  • (2023), Psychopharmacology (Berl), 240, pp. 2015, 10.1007/s00213-023-06431-6
  • (2018), BMC Psychiatry, 18, pp. 399, 10.1186/s12888-018-1993-3
  • (2024), Expert Opin Drug Saf, pp. 1
  • (2024), Schizophr Res, 268, pp. 265, 10.1016/j.schres.2023.11.008
  • (2022), Schizophr Bull, 48, pp. 655, 10.1093/schbul/sbac014
  • (2022), Br J Psychiatry, 221, pp. 758, 10.1192/bjp.2022.117
  • (2023), Schizophr Res, 252, pp. 208, 10.1016/j.schres.2023.01.018
  • (2024), Suicide Life Threat Behav, 54, pp. 972, 10.1111/sltb.13099
  • (2019), Sleep Med Rev, 44, pp. 37, 10.1016/j.smrv.2018.12.005
  • (2012), J Clin Psychiatry, 73, pp. e1160, 10.4088/JCP.11r07586
  • (2024), Span J psychiatry Ment Health, S2950-2853, pp. 00037
  • (2024), Eur Child Adolesc Psychiatry
  • (2024), Front Pharmacol, 15, pp. 1443555, 10.3389/fphar.2024.1443555
  • (2017), CNS Drugs, 31, pp. 699, 10.1007/s40263-017-0448-6
  • (2020), Psychiatry Res, 290, pp. 113048, 10.1016/j.psychres.2020.113048
  • (2021), Psychiatry Res, 300, pp. 113911, 10.1016/j.psychres.2021.113911
  • (2022), Br J Psychiatry, 220, pp. 365
  • (2017), Gen Hosp Psychiatry, 46, pp. 32, 10.1016/j.genhosppsych.2017.02.004
  • (2016), Int J Mol Sci, 17, pp. 863, 10.3390/ijms17060863
  • (2017), CNS Drugs, 31, pp. 1083, 10.1007/s40263-017-0481-5
  • (2007), Arch Intern Med, 167, pp. 1752, 10.1001/archinte.167.16.1752
  • (2022), Epidemiol Psychiatr Sci, 31, pp. e83, 10.1017/S204579602200066X
  • (2004), Pharmacopsychiatry, 37, pp. 243, 10.1055/s-2004-832687
  • (2020), J Clin Psychiatry, 81, pp. 19cs13169
  • (2019), Neuropsychiatr Dis Treat, 15, pp. 2365, 10.2147/NDT.S216803
  • (1977), Acta Psychiatr Scand, 56, pp. 241, 10.1111/j.1600-0447.1977.tb00224.x
  • (2024), Schizophr Res, 268, pp. 94
  • (2024), Lancet Psychiatry, 11, pp. 27, 10.1016/S2215-0366(23)00343-7
  • (2024), Schizophr Res, 268, pp. 74
  • (2023), Schizophr Bull, 49, pp. 962, 10.1093/schbul/sbad030
  • (2022), Schizophrenia (Heidelb), 8, pp. 21, 10.1038/s41537-022-00232-0
  • (2024), J Psychopharmacol, 38, pp. 624, 10.1177/02698811241262767
  • (2023), Br J Psychiatry, 223, pp. 382, 10.1192/bjp.2023.44
  • (2023), JAMA Psychiatry, 80, pp. 535, 10.1001/jamapsychiatry.2023.0376
  • (2024), Br J Psychiatry, 225, pp. 484, 10.1192/bjp.2024.104
  • (2025), Br J Psychiatry, 226, pp. 1, 10.1192/bjp.2024.150
  • (2022), J Clin Psychopharmacol, 42, pp. 565, 10.1097/JCP.0000000000001606
  • (2023), Expert Rev Clin Pharmacol, 16, pp. 177, 10.1080/17512433.2023.2183192
  • (2023), J Psychopharmacol, 37, pp. 135, 10.1177/02698811221142575
  • (2024), Schizophr Bull, 50, pp. 1287, 10.1093/schbul/sbae034
  • (2024), Schizophr Res, 263, pp. 275, 10.1016/j.schres.2022.09.021
  • (2024), Schizophr Res, 263, pp. 265, 10.1016/j.schres.2022.11.015
  • (2023), Exp Rev Clin Pharmacol, 16, pp. 865, 10.1080/17512433.2023.2243820
  • (2020), J Psychiatr Res, 125, pp. 21, 10.1016/j.jpsychires.2020.02.026
  • (2023), Br J Psychiatry, 223, pp. 456, 10.1192/bjp.2023.75
  • (2023), J Affect Disord, 333, pp. 403, 10.1016/j.jad.2023.04.030
  • (2024), Lancet Psychiatry, 11, pp. 210, 10.1016/S2215-0366(24)00006-3
  • (2024), World Psychiatry, 23, pp. 276, 10.1002/wps.21205
  • (2020), Int Clin Psychopharmacol, 35, pp. 129, 10.1097/YIC.0000000000000306
  • (2021), Schizophr Res, 228, pp. 367, 10.1016/j.schres.2021.01.015
  • (2018), J Pers Disord, 32, pp. 823, 10.1521/pedi_2017_31_328
  • (2023), Acta Psychiatr Scand, 147, pp. 603, 10.1111/acps.13564
  • (1994), Biol Psychiatry, 35, pp. 408, 10.1016/0006-3223(94)90008-6
  • (1996), Schizophr Bull, 22, pp. 455, 10.1093/schbul/22.3.455
  • (2024), Expert Rev Clin Pharmacol, 17, pp. 923, 10.1080/17512433.2024.2410395
  • (2024), Schizophr Res, 268, pp. 282
  • (2024), Ther Drug Monitor, 46, pp. 170, 10.1097/FTD.0000000000001154
  • (2014), Eur Psychiatry, 29, pp. 1
  • (2018), J Child Adolesc Psychopharmacol, 28, pp. 615, 10.1089/cap.2018.0036
  • (2022), J Child Adolesc Psychopharmacol, 32, pp. 2, 10.1089/cap.2021.0092
  • (2022), J Clin Psychopharmacol, 42, pp. 198, 10.1097/JCP.0000000000001506
  • (2024), Schizophr Res, 268, pp. 53, 10.1016/j.schres.2023.09.002
  • (2024), Schizophr Res, 268, pp. 60
  • (2024), Clin Psychopharmacol Neurosci, 22, pp. 442, 10.9758/cpn.24.1174
  • (2024), Schizophr Res, 268, pp. 25, 10.1016/j.schres.2023.03.048
  • (2024), Schizophr Res, 268, pp. 38, 10.1016/j.schres.2023.09.020
  • (2024), Schizophr Res, 268, pp. 21, 10.1016/j.schres.2023.10.002
  • (2018), Eur J Clin Pharmacol, 74, pp. 811, 10.1007/s00228-018-2431-7
  • (2024), JAMA Psychiatry, 81, pp. 639, 10.1001/jamapsychiatry.2024.0702
  • (2020), Schizophr Res, 216, pp. 2, 10.1016/j.schres.2019.12.009
  • (2024), Schizophr Res, 268, pp. 1
  • (2020), Gen Psychiatr, 33, pp. e100183, 10.1136/gpsych-2019-100183