Additional Supplement Data of the manuscript "Multi-Ancestry Epigenome-Wide Association Study of Asthma Exacerbations""

  1. Martin-Gonzalez, Elena 1
  2. Perez-Garcia, Javier 1
  3. Martin-Almeida, Mario 1
  4. Witonsky, Jonathan 2
  5. Eng, Celeste 2
  6. Huntsman, Scott 2
  7. Hu, Donglei 2
  8. Lorenzo, Fabian 1
  9. González Pérez, Ruperto 3
  10. Hernández Pérez, José María 45
  11. Poza Guedes, Paloma 3
  12. sardon, olaia 67
  13. Sanchez-Machin, Inmaculada 3
  14. Mederos-Luis, Elena 3
  15. Corcuera, Paula 8
  16. Villar, Jesús 9101112
  17. Rodriguez-Santana, Jose 13
  18. Ziv, Elad 2
  19. Burchard, Esteban 2
  20. Pino-Yanes, Maria 1
  1. 1 Universidad de La Laguna
    info
    Universidad de La Laguna

    San Cristobal de La Laguna, España

    ROR https://ror.org/01r9z8p25

    Geographic location of the organization Universidad de La Laguna
  2. 2 University of California, San Francisco
    info
    University of California, San Francisco

    San Francisco, Estados Unidos

    ROR https://ror.org/043mz5j54

    Geographic location of the organization University of California, San Francisco
  3. 3 Hospital Universitario de Canarias
    info
    Hospital Universitario de Canarias

    San Cristóbal de La Laguna, España

    ROR https://ror.org/05qndj312

    Geographic location of the organization Hospital Universitario de Canarias
  4. 4 Hospital Universitario Nuestra Señora de Candelaria
    info
    Hospital Universitario Nuestra Señora de Candelaria

    Santa Cruz de Tenerife, España

    ROR https://ror.org/005a3p084

    Geographic location of the organization Hospital Universitario Nuestra Señora de Candelaria
  5. 5 Hospital General de La Palma
    info
    Hospital General de La Palma

    Brena Alta, España

    Geographic location of the organization Hospital General de La Palma
  6. 6 University of the Basque Country (EHU/UPV)
  7. 7 Donostia University Hospital
  8. 8 Servicio Vasco de Salud
    info
    Servicio Vasco de Salud

    Vitoria-Gasteiz, España

    Geographic location of the organization Servicio Vasco de Salud
  9. 9 Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias
    info
    Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias

    Madrid, España

    Geographic location of the organization Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias
  10. 10 Hospital de Gran Canaria Dr. Negrin
    info
    Hospital de Gran Canaria Dr. Negrin

    Las Palmas de Gran Canaria, España

    ROR https://ror.org/00s4vhs88

    Geographic location of the organization Hospital de Gran Canaria Dr. Negrin
  11. 11 Universidad del Atlántico Medio
  12. 12 St. Michael's Hospital
    info
    St. Michael's Hospital

    Toronto, Canadá

    ROR https://ror.org/04skqfp25

    Geographic location of the organization St. Michael's Hospital
  13. 13 Centro de Neumología Pediátrica, San Juan, Puerto Rico, USA.
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Editor: Zenodo

Year of publication: 2025

Type: Dataset

Version: 1

CC BY 4.0

DOI: 10.5281/ZENODO.14851967 lock_openOpen access editor
Dataset versions:
Version Created DOI
1 22-08-2025 10.5281/zenodo.14851968

Abstract

For this manuscript we conducted a meta-analysis from epigenome-wide association study of asthma exacerbations in 599 Latino and 394 African Americans as discovery ("2_EWAS_MetaResults_Multiancestry_GALA_SAGE__bacon_exacerbations_mval_lineal_age_sex_pcs_rcs_filtered.txt"). In addition, we also performed a multi-ancestry meta-analysis including GEMAS study, which included 312 Canary Islanders and 94 Basques ("2_EWAS_MetaResults_Multiancestry_GALA_SAGE_CAN_PV_bacon_exacerbations_mval_lineal_age_sex_pcs_rcs_filtered.txt").  Summary statistics output is organized in the following columns: RSID: Probe ID STUDY: number of studies or subsets were is present the probe BETA_meta:  coefficient estimate SEBETA_meta:  standard error PVALUE_meta: raw p-value  PVALUE_Q: p-value of Cochran’s Q Model: FE (fixed effect) or RE2 (random effect) PVALUE_meta_adj: adjusted p-value by false discovery rate