Additional Supplement Data of the manuscript "Genome-Wide Association Study of Asthma Exacerbations in the Spanish Population"

  1. Martin-Gonzalez, Elena 1
  2. Perez-Garcia, Javier 1
  3. Martin-Almeida, Mario 1
  4. Hernández Pérez, José María 23
  5. González Pérez, Ruperto 4
  6. sardon, olaia 56
  7. Pérez Pérez, José Antonio 1
  8. González, Mario 1
  9. Poza Guedes, Paloma 4
  10. Sanchez-Machin, Inmaculada 4
  11. Mederos-Luis, Elena 4
  12. Corcuera, Paula 7
  13. López-Fernández, Leyre 8
  14. Román-Bernal, Berta 9
  15. González García., Luis Manuel 10
  16. Cruz, María J 11
  17. Gonzalez-Barcala, Francisco-Javier 1213
  18. Martinez Rivera, Carlos 14
  19. Mullol, Joaquim 15
  20. Muñoz, Xavier
  21. Olaguibel, Jose M 16
  22. Plaza, Vicente
  23. Quirce, Santiago 17
  24. Valero, Antonio
  25. Sastre, Joaquin 1819
  26. DEL POZO, VICTORIA
  27. Villar, Jesús 20
  28. Lorenzo, Fabian 1
  29. Pino-Yanes, Maria 1
  30. Show all authors +
  1. 1 Universidad de La Laguna
    info
    Universidad de La Laguna

    San Cristobal de La Laguna, España

    ROR https://ror.org/01r9z8p25

    Geographic location of the organization Universidad de La Laguna
  2. 2 Hospital Universitario Nuestra Señora de Candelaria
    info
    Hospital Universitario Nuestra Señora de Candelaria

    Santa Cruz de Tenerife, España

    ROR https://ror.org/005a3p084

    Geographic location of the organization Hospital Universitario Nuestra Señora de Candelaria
  3. 3 Hospital General de La Palma
    info
    Hospital General de La Palma

    Brena Alta, España

    Geographic location of the organization Hospital General de La Palma
  4. 4 Hospital Universitario de Canarias
    info
    Hospital Universitario de Canarias

    San Cristóbal de La Laguna, España

    ROR https://ror.org/05qndj312

    Geographic location of the organization Hospital Universitario de Canarias
  5. 5 University of the Basque Country (EHU/UPV)
  6. 6 Donostia University Hospital
  7. 7 Servicio Vasco de Salud
    info
    Servicio Vasco de Salud

    Vitoria-Gasteiz, España

    Geographic location of the organization Servicio Vasco de Salud
  8. 8 Division of Pediatric Respiratory Medicine, Hospital Universitario Donostia, San Sebastián, Spain.
  9. 9 Respiratory Medicine, Hospital Dr. José Molina Orosa, Arrecife, Las Palmas, Spain.
  10. 10 Servicio Canario de la Salud
  11. 11 CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain; Departamento de Medicina Respiratoria, Hospital Vall d'Hebron, Barcelona, Spain.
  12. 12 Universidade de Santiago de Compostela
    info
    Universidade de Santiago de Compostela

    Santiago de Compostela, España

    ROR https://ror.org/030eybx10

    Geographic location of the organization Universidade de Santiago de Compostela
  13. 13 Complexo Hospitalario Universitario de Santiago
    info
    Complexo Hospitalario Universitario de Santiago

    Santiago de Compostela, España

    ROR https://ror.org/00mpdg388

    Geographic location of the organization Complexo Hospitalario Universitario de Santiago
  14. 14 Hospital Universitari Germans Trias i Pujol
    info
    Hospital Universitari Germans Trias i Pujol

    Barcelona, España

    ROR https://ror.org/04wxdxa47

    Geographic location of the organization Hospital Universitari Germans Trias i Pujol
  15. 15 IDIBAPS - Hospital Clínic
  16. 16 Complejo Hospitalario de Navarra
  17. 17 Hospital Universitario La Paz
    info
    Hospital Universitario La Paz

    Madrid, España

    ROR https://ror.org/01s1q0w69

    Geographic location of the organization Hospital Universitario La Paz
  18. 18 Universidad Autónoma de Madrid Facultad de Medicina
  19. 19 Fundación Jiménez Díaz
    info
    Fundación Jiménez Díaz

    Madrid, España

    ROR https://ror.org/049nvyb15

    Geographic location of the organization Fundación Jiménez Díaz
  20. 20 CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain; Research Unit at Hospital Universitario Dr. Negrín, Fundación Canaria Instituto de Investigación Sanitaria de Canarias, Las Palmas, Spain; Faculty of Health Sciences, Universidad del Atlántico Medio, Tafira Baja, Las Palmas, Spain; Li Ka Shing Knowledge Institute at St Michael's Hospital, Toronto, Canada.
Show affiliations +

Editor: Zenodo

Year of publication: 2025

Type: Dataset

Version: 1

CC BY 4.0

DOI: 10.5281/ZENODO.14857203 lock_openOpen access editor
Dataset versions:
Version Created DOI
1 22-08-2025 10.5281/zenodo.14857204

Abstract

For this manuscript we conducted a meta-analysis from genome-wide association study of asthma exacerbations in 345 adults from the Genomics and Metagenomics of Asthma Severity (GEMAS), 369 from Characterizing Alpha-1-Antitrypsin Deficiency in patients with pulmonary diseases (CAATDPUL), and 138 from MEchanisms involved in the Genesis and evolution of Asthma (MEGA) studies as discovery. Summary statistics output is organized in the following columns: RSID: Variant ID based on chromosome:position:effect allele:rsID STUDY: number of studies or subsets were is present the probe BETA_meta:  coefficient estimate SEBETA_meta:  standard error PVALUE_meta: raw p-value  PVALUE_Q: p-value of Cochran’s Q Model: FE (fixed effect) or RE2 (random effect) PVALUE_meta_adj: adjusted p-value by false discovery rate BP: Genomic positions are indicated in GRCh38 Genome Assembly CHR: Chromosome