Caracterización del homólogo de KU70 en Candida albicansAnálisis de la función de la proteína en el mantenimiento de los telómeros

  1. Lidia Chico Domínguez
Supervised by:
  1. Germán Larriba Calle Director
  2. Antonia Ciudad Sánchez Director

Defence university: Universidad de Extremadura

Year of defence: 2009

Committee:
  1. Tomás González Villa Chair
  2. María Encarnación Andaluz López Secretary
  3. Carlos Gutiérrez Merino Committee member
  4. Luis Rodriguez Dominguez Committee member
  5. Tahía Benítez Fernández Committee member

Type: Thesis

Teseo: 260542 DIALNET

Abstract

The heterodimeric Ku complex has been shown to participate in DNA repair and telomere regulation in a variety of organisms. Here we report a detailed characterization of the function of Ku70 in the diploid fungal pathogen Candida albicans by anslysis of ku70 heterozygous and homozygous deletion mutants and their reconstituted strains, and its role in telomere maintenance.