Transporte del ß-amilode a través de las barreras cerebrales y su posible implicación en el desarrollo de la enfermedad de Alzheimer

  1. Ibrahim González Marrero
  2. Leandro Castañeyra Ruiz
  3. María Castañeyra Ruiz
  4. Juan M. González Toledo
  5. Emilia María Carmona Calero
Journal:
Majorensis: Revista Electrónica de Ciencia y Tecnología

ISSN: 1697-5529

Year of publication: 2014

Issue: 10

Pages: 7-15

Type: Article

Export: RIS

Abstract

ß-amyloid transport through the brain barrier and its possible role in the development of Alzheimer's disease. The clearance of ß-amyloid, through its accurate metabolism in the brain, is essential to prevent neurodegenerative diseases such as Alzheimer's disease (AD). Thus, it is postulated that a defective ß-amyloid clearance by brain barriers, both the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (BCSFB) barrier, could be an important factor in the onset and development of AD. The ß-amyloid (ßA) located in the interstitial fluid (IF) can pass to the blood through the BBB or passively move to LCR where ßA is kidnapped by the choroid plexus from CSF into the blood. It is proposed that the cause of most cases of sporadic AD (late onset), may be due to improper clearance of ß-amyloid in the brain, so that dementia in AD could be associated with the brain barrier disorder, leading to the accumulation of ß-amyloid on blood vessels, the brain parenchyma , and extracellular and intraneuronal form deposits.