Efectos de la administración de nicotina sobre la eminencia media y el núcleo arcuato. Estudio con tirosina hidroxilasa y angiotensina II

  1. Emilia María Carmona Calero
  2. Agustín Castañeyra Ruiz
  3. Ibrahim González Marrero
  4. Héctor de Paz Carmona
  5. Juan M. González Toledo
  6. Isabel González Garde
  7. Agustín Lorenzo Castañeyra Perdomo
Majorensis: Revista Electrónica de Ciencia y Tecnología

ISSN: 1697-5529

Year of publication: 2007

Issue: 3

Pages: 18-22

Type: Article

More publications in: Majorensis: Revista Electrónica de Ciencia y Tecnología


The nicotine is one of the main factors responsible of the acute affections of cardiovascular system. For another hand, the median eminence and the arcuate nucleus belong to the tubeoinfudibular system where catecholaminergic and vasopressinergic neurones and fibres are observed. The aim of the present work is to analyze the effects of the nicotine administration on the ME and AN. Female mouse divided in four groups were used; control groups of 50 and 85 days of age and experimental groups that were treated with nicotine during 30 and 60 days and were sacrificed at the same age than control groups. For the immunohistochemistry anti-tyrosine-hydroxylase (TH) and anti-vasopressin II (AgII) were used as primary antibodies. The results showed that nicotine treatment produced a decrease of the TH-ir in the ME and AN. Contrarily the AgII-ir was increased in the ME and did not showed changes in the AN. The nicotine produces decrease of the TH and an increase of the AgII, in similar way that is described for the hypertensive rats, that could be related with the nicotine effects on the release of the neurotransmitter