Efectos de la castración perinatal y prepuberal sobre la amígdala cerebral
- Emilia Mª Carmona-Calero 1
- Juan M. Gonzalez-Toledo 1
- Paula Soberón-Rodríguez 1
- Rosa J. Tejera-Pérez 1
- Bárbara Agostina-Valenzuela 1
- Leandro Castañeyra-Ruiz 1
- Luis G Hernandez-Abad 2
- Ibrahim González-Marrero 1
- Agustín Castañeyra-Perdomo 1
- 1 Universidad de La Laguna (ESP)
- 2 Instituto de Investigación y Ciencias, Puerto del Rosario, Fuerteventura
ISSN: 1697-5529
Year of publication: 2017
Issue: 13
Pages: 11-20
Type: Article
More publications in: Majorensis: Revista Electrónica de Ciencia y Tecnología
Abstract
The amygdala is considered as the center of the emotions and regulator of reactions of aggressiveness, fear and anxiety. In humans the amygdala is associated with emotional learning and social behavior. The amygdala also plays an important role in sexual behavior. In our study, we used as experimental animal male mice divided into: a control group and two experimental groups formed by newborn castrated mice and pre-puberty castrated mice. They were sacrificed at 5, 35 and 85 days of age. The histological techniques used were Klüver-Barrera and immunohistochemistry with anti-NeuN. Pre-puberty castration affected very little the parts of the amygdala complex. In contrast, neonatal castration produced changes in the neurons of the medial nucleus of the amygdala showed different density and neuronal nuclear area as they are: the number of neurons presents a marked decrease in castrated mice Neonates and a decrease in the size of most nuclei of medial amygdala neurons at 35 and 85 days of age. We can conclude that pre-puberty castration (20 days) affects very little the global and neural morphology of the different parts of the tonsillar complex. In contrast, castration in neonates induces variations in the medial tonsillar nuclei that are most related to the sexual maturation of the brain described in the mouse in the first postnatal days