Efectos de la Hipertensión arterial sobre el área postrema. Estudio en ratas SHR
- Martínez de la Peña Valenzuela, Isabel
- Carmona Calero, Emilia María
- León Cabrera, Teresa de
- Pérez González, Herminia Calixta
- Marrero Gordillo, Norberto
- Castañeyra Perdomo, Agustín Lorenzo
ISSN: 1697-5529
Ano de publicación: 2002
Número: 1
Páxinas: 1-19
Tipo: Artigo
Outras publicacións en: Majorensis: Revista Electrónica de Ciencia y Tecnología
Resumo
Arterial hypertension effects on the area postrema. A study in SHR rats.- We studied qualitative and quantitatively the area postrema (AP) of 10 and 15-week old spontaneously hypertensive rats (SHR) and of matched normotensive Wistar Kyoto rats (WKY). The blood pressure, water and saline intake were also recorded. The SHR rats drank more saline than water. The nuclear size of the neurones of rostral part AP in the SHR animals showed an increase respect to the nuclear size of the neurones of rostral and caudal part AP of WKY rats. This increase of the nuclear size is compatible with the hyperactivity of the brain RAS and the increase of the nuclear parameters and AGII receptors in the others circumventricular organs. On the other hand, theses findings and the fact that hypertension is accompanied by a progressive ventricular dilation support the possibility that in the hypertensive rats the secretor material released by the CVO into the CSF is altered owing to hyperfuntion of the rostral AP and the others CVO.