Papel de la eminencia talámica, el sistema olfativo principal y el sistema olfativo accesorio en la maduración sexual del encéfalo y las manifestaciones clínico-morfológicas del síndrome de Kallmann

  1. Leandro Castañeyra Ruiz 2
  2. María Nélida Rancel Torres 2
  3. María Castañeyra Ruiz 2
  4. Juan M. González Toledo 2
  5. Marina Gutiérrez Vilar 2
  6. Julio A. Hernández García 2
  7. Patricia Hernández Gutiérrez 2
  8. Clara Blasco Igual 1
  9. Francisco José Pérez Moltó 1
  10. Ibrahim González Marrero 2
  1. 1 Universitat de València
    info

    Universitat de València

    Valencia, España

    GRID grid.5338.d

  2. 2 Universidad de La Laguna
    info

    Universidad de La Laguna

    San Cristobal de La Laguna, España

    GRID grid.10041.34

Journal:
Majorensis: Revista Electrónica de Ciencia y Tecnología

ISSN: 1697-5529

Year of publication: 2014

Issue: 10

Pages: 37-44

Type: Article

Export: RIS

Abstract

The olfactory system development and brain sexual maturation, in man and animals, are closely related. Currently the overlap between the formation of the olfactory system and the migration of neurons that synthesize gonadotropin-releasing hormone (GnRF) are described. The GnRF neurons migrate from the medial portion of the nasal epithelium through the olfactory nerves and the main olfactory bulb to the anterior hypothalamus. Furthermore, Kallmann syndrome (KS) is a genetic disorder in which combines hypogonadotropic hypogonadism and anosmia. Hypogonadism is characterized by the absence or reduced levels of gonadotropin-releasing hormone and anosmia is due to aplasia of the olfactory bulb. The basic clinical manifestations of KS are: anosmia and the absence of puberty. The structures responsible for the maturation of the main and accessory olfactory systems, the sexual differentiation of the brain and its relationship with all the clinical manifestations of Kallmann syndrome are analyzed in this review.