Control presináptico por receptores acoplados a proteínas G, GPCRs, en un ratón modelo del síndrome X frágil

  1. Garcia Font, Nuria
unter der Leitung von:
  1. José Sánchez-Prieto Borja Doktorvater/Doktormutter
  2. María Jesús Oset Gasque Doktorvater/Doktormutter

Universität der Verteidigung: Universidad Complutense de Madrid

Fecha de defensa: 21 von November von 2019

  1. Miguel Díaz Hernández Präsident/in
  2. Jesús Miguel Pradillo Justo Sekretär/in
  3. José María Solís Torralba Vocal
  4. David Bartolomé Martín Vocal
  5. Gertrudis Perea Parrilla Vocal

Art: Dissertation


Fragile X syndrome (FXS) is the most common inherited intellectual disability and it is associated with multiple behavioral alterations, including cognitive deficits, hyperactivity, anxiety and deficits in social behavior. In FXS, the Fmr1 gene that encodes the fragile mental retardation protein (FMRP) is silenced. FMRP modulates gene expression through changes in the stability and transport of its mRNA targets. When FMRP is absent the expression of many postsynaptic proteins is altered as well as postsynaptic long-term forms of plasticity. FMRP is also found in axons and presynaptic nerve terminals and mRNA targets encoding for presynaptic proteins were identified...