Association between telomere length and risk of cancer and non-neoplastic diseases a mendelian randomization study

  1. Haycock, P.C. 11
  2. Burgess, S. 2
  3. Nounu, A. 11
  4. Zheng, J. 11
  5. Okoli, G.N. 1
  6. Bowden, J. 11
  7. Wade, K.H. 11
  8. Timpson, N.J. 11
  9. Evans, D.M. 113
  10. Willeit, P. 4
  11. Aviv, A. 5
  12. Gaunt, T.R. 11
  13. Hemani, G. 11
  14. Mangino, M. 67
  15. Ellis, H.P. 1
  16. Kurian, K.M. 1
  17. Pooley, K.A. 2
  18. Eeles, R.A. 8
  19. Lee, J.E. 9
  20. Fang, S. 9
  21. Chen, W.V. 9
  22. Law, M.H. 10
  23. Bowdler, L.M. 11
  24. Iles, M.M. 12
  25. Yang, Q. 13
  26. Worrall, B.B. 14
  27. Markus, H.S. 2
  28. Hung, R.J. 1516
  29. Amos, C.I. 17
  30. Spurdle, A.B. 18
  31. Thompson, D.J. 2
  32. O'Mara, T.A. 18
  33. Wolpin, B. 19
  34. Amundadottir, L. 20
  35. Stolzenberg-Solomon, R. 20
  36. Trichopoulou, A. 2122
  37. Onland-Moret, N.C. 23
  38. Lund, E. 24
  39. Duell, E.J. 25
  40. Canzian, F. 26
  41. Severi, G. 27282930
  42. Overvad, K. 31
  43. Gunter, M.J. 32
  44. Tumino, R. 33
  45. Svenson, U. 34
  46. Van Rij, A. 35
  47. Baas, A.F. 23
  48. Bown, M.J. 36
  49. Samani, N.J. 36
  50. Van t'Hof, F.N.G. 23
  51. Tromp, G. 3738
  52. Jones, G.T. 35
  53. Kuivaniemi, H. 3738
  54. Elmore, J.R. 39
  55. Johansson, M. 40
  56. Mckay, J. 40
  57. Scelo, G. 40
  58. Carreras-Torres, R. 40
  59. Gaborieau, V. 40
  60. Brennan, P. 40
  61. Bracci, P.M. 41
  62. Neale, R.E. 11
  63. Olson, S.H. 42
  64. Gallinger, S. 15
  65. Li, D. 9
  66. Petersen, G.M. 43
  67. Risch, H.A. 44
  68. Klein, A.P. 45
  69. Han, J. 4647
  70. Abnet, C.C. 20
  71. Freedman, N.D. 20
  72. Taylor, P.R. 20
  73. Maris, J.M. 48
  74. Aben, K.K. 4950
  75. Kiemeney, L.A. 49
  76. Vermeulen, S.H. 49
  77. Wiencke, J.K. 4141
  78. Walsh, K.M. 4141
  79. Wrensch, M. 4141
  80. Rice, T. 41
  81. Turnbull, C. 851
  82. Litchfield, K. 52
  83. Paternoster, L. 11
  84. Standl, M. 53
  85. Abecasis, G.R. 54
  86. SanGiovanni, J.P. 5556
  87. Li, Y. 57
  88. Mijatovic, V. 58
  89. Sapkota, Y. 11
  90. Low, S.-K. 59
  91. Zondervan, K.T. 6061
  92. Montgomery, G.W. 11
  93. Nyholt, D.R. 1162
  94. Van Heel, D.A. 51
  95. Hunt, K. 51
  96. Arking, D.E. 45
  97. Ashar, F.N. 45
  98. Sotoodehnia, N. 63
  99. Woo, D. 64
  100. Rosand, J. 65
  101. Comeau, M.E. 66
  102. Brown, W.M. 66
  103. Silverman, E.K. 67
  104. Hokanson, J.E. 68
  105. Cho, M.H. 67
  106. Hui, J. 69707172
  107. Ferreira, M.A. 11
  108. Thompson, P.J. 71
  109. Morrison, A.C. 73
  110. Felix, J.F. 74
  111. Smith, N.L. 63
  112. Christiano, A.M. 75
  113. Petukhova, L. 75
  114. Betz, R.C. 76
  115. Fan, X. 77
  116. Zhang, X. 77
  117. Zhu, C. 77
  118. Langefeld, C.D. 66
  119. Thompson, S.D. 78
  120. Wang, F. 79
  121. Lin, X. 79
  122. Schwartz, D.A. 80
  123. Fingerlin, T. 81
  124. Rotter, J.I. 8283
  125. Cotch, M.F. 84
  126. Jensen, R.A. 6363
  127. Munz, M. 8586
  128. Dommisch, H. 85
  129. Schaefer, A.S. 85
  130. Han, F. 87
  131. Ollila, H.M. 88
  132. Hillary, R.P. 88
  133. Albagha, O. 8990
  134. Ralston, S.H. 90
  135. Zeng, C. 91
  136. Zheng, W. 91
  137. Shu, X.-O. 91
  138. Reis, A. 92
  139. Uebe, S. 92
  140. Hüffmeier, U. 92
  141. Kawamura, Y. 93
  142. Otowa, T. 9495
  143. Sasaki, T. 94
  144. Hibberd, M.L. 96
  145. Davila, S. 97
  146. Xie, G. 1516
  147. Siminovitch, K. 1516
  148. Bei, J.-X. 98
  149. Zeng, Y.-X. 9899
  150. Försti, A. 26100
  151. Chen, B. 26
  152. Landi, S. 101
  153. Franke, A. 102
  154. Fischer, A. 102103
  155. Ellinghaus, D. 103
  156. Flores, C. 104105
  157. Noth, I. 106
  158. Ma, S.-F. 106
  159. Foo, J.N. 107
  160. Liu, J. 107
  161. Kim, J.-W. 108
  162. Cox, D.G. 109
  163. Delattre, O. 110
  164. Mirabeau, O. 110
  165. Skibola, C.F. 111
  166. Tang, C.S. 112
  167. Garcia-Barcelo, M. 112
  168. Chang, K.-P. 113
  169. Su, W.-H. 113114
  170. Chang, Y.-S. 114
  171. Martin, N.G. 11
  172. Gordon, S. 11
  173. Wade, T.D. 115
  174. Lee, C. 116
  175. Kubo, M. 117
  176. Cha, P.-C. 118
  177. Nakamura, Y. 119
  178. Levy, D. 120121
  179. Kimura, M. 5
  180. Hwang, S.-J. 120121
  181. Hunt, S. 122
  182. Spector, T. 6
  183. Soranzo, N. 123
  184. Manichaikul, A.W. 14
  185. Barr, R.G. 124
  186. Kahali, B. 125
  187. Speliotes, E. 125
  188. Yerges-Armstrong, L.M. 126
  189. Cheng, C.-Y. 127128129
  190. Jonas, J.B. 130131
  191. Wong, T.Y. 127128129
  192. Fogh, I. 6
  193. Lin, K. 6
  194. Powell, J.F. 6
  195. Rice, K. 63
  196. Relton, C.L. 11
  197. Martin, R.M. 111
  198. Davey Smith, G. 11
  199. Show all authors +
  1. 1 University of Bristol
    info

    University of Bristol

    Brístol, Reino Unido

    ROR https://ror.org/0524sp257

  2. 2 University of Cambridge
    info

    University of Cambridge

    Cambridge, Reino Unido

    ROR https://ror.org/013meh722

  3. 3 University of Queensland
    info

    University of Queensland

    Brisbane, Australia

    ROR https://ror.org/00rqy9422

  4. 4 University of Innsbruck
    info

    University of Innsbruck

    Innsbruck, Austria

    ROR https://ror.org/054pv6659

  5. 5 Center of Human Development and Aging, Department of Pediatrics, New Jersey Medical School, Rutgers, The State University of New Jersey
  6. 6 King's College London
    info

    King's College London

    Londres, Reino Unido

    ROR https://ror.org/0220mzb33

  7. 7 Guy's Hospital
    info

    Guy's Hospital

    Londres, Reino Unido

    ROR https://ror.org/04r33pf22

  8. 8 Institute of Cancer Research, Royal Marsden NHS Foundation Trust
  9. 9 University of Texas MD Anderson Cancer Center
    info

    University of Texas MD Anderson Cancer Center

    Houston, Estados Unidos

    ROR https://ror.org/04twxam07

  10. 10 Statistical Genetics, QIMR Berghofer Medical Research Institute
  11. 11 QIMR Berghofer Medical Research Institute
    info

    QIMR Berghofer Medical Research Institute

    Brisbane, Australia

    ROR https://ror.org/004y8wk30

  12. 12 University of Leeds
    info

    University of Leeds

    Leeds, Reino Unido

    ROR https://ror.org/024mrxd33

  13. 13 Boston University
    info

    Boston University

    Boston, Estados Unidos

    ROR https://ror.org/05qwgg493

  14. 14 University of Virginia
    info

    University of Virginia

    Charlottesville, Estados Unidos

    ROR https://ror.org/0153tk833

  15. 15 Mount Sinai Hospital
    info

    Mount Sinai Hospital

    Toronto, Canadá

    ROR https://ror.org/05deks119

  16. 16 University of Toronto
    info

    University of Toronto

    Toronto, Canadá

    ROR https://ror.org/03dbr7087

  17. 17 Dartmouth College
    info

    Dartmouth College

    Hanover, Estados Unidos

    ROR https://ror.org/049s0rh22

  18. 18 Genetics and Computational Biology Division, QIMR Berghofer Medical Research Institute
  19. 19 Dana–Farber Cancer Institute
    info

    Dana–Farber Cancer Institute

    Boston, Estados Unidos

    ROR https://ror.org/02jzgtq86

  20. 20 National Cancer Institute
    info

    National Cancer Institute

    Rockville, Estados Unidos

    ROR https://ror.org/040gcmg81

  21. 21 Hellenic Health Foundation
    info

    Hellenic Health Foundation

    Atenas, Grecia

    ROR https://ror.org/02wncmm17

  22. 22 National and Kapodistrian University of Athens
    info

    National and Kapodistrian University of Athens

    Atenas, Grecia

    ROR https://ror.org/04gnjpq42

  23. 23 University Medical Center Utrecht
    info

    University Medical Center Utrecht

    Utrecht, Holanda

    ROR https://ror.org/0575yy874

  24. 24 Institute of Community Medicine, UiT The Arctic University of Norway
  25. 25 Institute Catalá Oncología
    info

    Institute Catalá Oncología

    Barcelona, España

    ROR https://ror.org/01j1eb875

  26. 26 German Cancer Research Center
    info

    German Cancer Research Center

    Heidelberg, Alemania

    ROR https://ror.org/04cdgtt98

  27. 27 University of Paris-Sud
    info

    University of Paris-Sud

    Orsay, Francia

    ROR https://ror.org/028rypz17

  28. 28 Gustave Roussy Cancer Campus
    info

    Gustave Roussy Cancer Campus

    Villejuif, Francia

    ROR https://ror.org/0321g0743

  29. 29 Human Genetics Foundation (HuGeF)
  30. 30 University of Melbourne
    info

    University of Melbourne

    Melbourne, Australia

    ROR https://ror.org/01ej9dk98

  31. 31 Aarhus University
    info

    Aarhus University

    Århus, Dinamarca

    ROR https://ror.org/01aj84f44

  32. 32 Imperial College London
    info

    Imperial College London

    Londres, Reino Unido

    ROR https://ror.org/041kmwe10

  33. 33 Cancer Registry, Azienda Ospedaliera Civile M.P. Arezzo
  34. 34 Umeå University
    info

    Umeå University

    Umeå, Suecia

    ROR https://ror.org/05kb8h459

  35. 35 University of Otago
    info

    University of Otago

    Dunedin, Nueva Zelanda

    ROR https://ror.org/01jmxt844

  36. 36 University of Leicester
    info

    University of Leicester

    Leicester, Reino Unido

    ROR https://ror.org/04h699437

  37. 37 Stellenbosch University
    info

    Stellenbosch University

    Stellenbosch, Sudáfrica

    ROR https://ror.org/05bk57929

  38. 38 Sigfried and Janet Weis Center for Research, Geisinger Health System
  39. 39 Department of Vascular and Endovascular Surgery, Geisinger Health System
  40. 40 International Agency For Research On Cancer
    info

    International Agency For Research On Cancer

    Lyon, Francia

    ROR https://ror.org/00v452281

  41. 41 University of California, San Francisco
    info

    University of California, San Francisco

    San Francisco, Estados Unidos

    ROR https://ror.org/043mz5j54

  42. 42 Memorial Sloan Kettering Cancer Center
    info

    Memorial Sloan Kettering Cancer Center

    Nueva York, Estados Unidos

    ROR https://ror.org/02yrq0923

  43. 43 Department of Health Sciences Research, Mayo Clinic College of Medicine
  44. 44 Yale School of Public Health, Yale School of Medicine, Yale Cancer Center
  45. 45 Johns Hopkins University School of Medicine
    info

    Johns Hopkins University School of Medicine

    Baltimore, Estados Unidos

  46. 46 Indiana University – Purdue University Indianapolis
    info

    Indiana University – Purdue University Indianapolis

    Indianápolis, Estados Unidos

    ROR https://ror.org/05gxnyn08

  47. 47 Indiana University Melvin and Bren Simon Cancer Center
  48. 48 Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania
  49. 49 Radboud University Nijmegen Medical Centre
    info

    Radboud University Nijmegen Medical Centre

    Nimega, Holanda

    ROR https://ror.org/05wg1m734

  50. 50 Netherlands Comprehensive Cancer Organization
  51. 51 Queen Mary University of London
    info

    Queen Mary University of London

    Londres, Reino Unido

    ROR https://ror.org/026zzn846

  52. 52 Division of Genetics and Epidemiology, Institute of Cancer Research
  53. 53 Helmholtz Zentrum München
    info

    Helmholtz Zentrum München

    Múnich, Alemania

    ROR https://ror.org/00cfam450

  54. 54 Department of Biostatistics, University of Michigan
  55. 55 National Institute of Alcohol Abuse and Alcoholism, Laboratory of Membrane Biophysics and Biochemistry, Section on Nutritional Neuroscience
  56. 56 Department of Biochemistry and Molecular and Cellular Biology, Georgetown School of Medicine
  57. 57 University of Freiburg
    info

    University of Freiburg

    Friburgo de Brisgovia, Alemania

    ROR https://ror.org/0245cg223

  58. 58 University of Verona
    info

    University of Verona

    Verona, Italia

    ROR https://ror.org/039bp8j42

  59. 59 Laboratory of Statistical Analysis, Centre for Integrative Medical Sciences, Institute of Physical and Chemical Research (RIKEN)
  60. 60 Genetic and Genomic Epidemiology Unit, Wellcome Trust Centre for Human Genetics, University of Oxford
  61. 61 Nuffield Department of Obstetrics and Gynecology, University of Oxford, John Radcliffe Hospital
  62. 62 Queensland University of Technology
    info

    Queensland University of Technology

    Brisbane, Australia

    ROR https://ror.org/03pnv4752

  63. 63 University of Washington
    info

    University of Washington

    Seattle, Estados Unidos

    ROR https://ror.org/00cvxb145

  64. 64 University of Cincinnati College of Medicine, Department of Neurology
  65. 65 Massachusetts General Hospital
    info

    Massachusetts General Hospital

    Boston, Estados Unidos

    ROR https://ror.org/002pd6e78

  66. 66 Center for Public Health Genomics, Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine
  67. 67 Brigham and Women's Hospital
    info

    Brigham and Women's Hospital

    Boston, Estados Unidos

    ROR https://ror.org/04b6nzv94

  68. 68 Department of Epidemiology, University of Colorado Anschutz Medical Campus
  69. 69 Busselton Population Medical Research Institute Inc., Sir Charles Gairdner Hospital
  70. 70 PathWest Laboratory Medicine of Western Australia
  71. 71 University of Western Australia
    info

    University of Western Australia

    Perth, Australia

    ROR https://ror.org/047272k79

  72. 72 School of Population Health, University of WA
  73. 73 Department of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Science Center at Houston
  74. 74 Erasmus University Medical Center
    info

    Erasmus University Medical Center

    Róterdam, Holanda

    ROR https://ror.org/018906e22

  75. 75 Columbia University
    info

    Columbia University

    Nueva York, Estados Unidos

    ROR https://ror.org/00hj8s172

  76. 76 Institute of Human Genetics, University of Bonn
  77. 77 Institute of Dermatology, Department of Dermatology, Anhui Medical University
  78. 78 Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine
  79. 79 Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences
  80. 80 Department of Medicine, School of Medicine, University of Colorado
  81. 81 Department of Biomedical Research, National Jewish Health Hospital
  82. 82 Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Harbor- UCLA Medical Center
  83. 83 Departments of Pediatrics and Medicine, Harbor-UCLA Medical Center
  84. 84 Epidemiology Branch, Division of Epidemiology and Clinical Applications, Intramural Research Program, National Eye Institute, National Institutes of Health, Clinical Research Center
  85. 85 Charité
    info

    Charité

    Berlín, Alemania

    ROR https://ror.org/001w7jn25

  86. 86 University of Lubeck
    info

    University of Lubeck

    Lubeca, Alemania

    ROR https://ror.org/00t3r8h32

  87. 87 Department of Pulmonary Medicine, Peking University People's Hospital
  88. 88 Stanford University
    info

    Stanford University

    Stanford, Estados Unidos

    ROR https://ror.org/00f54p054

  89. 89 Qatar Biomedical Research Institute, Hamad Bin Khalifa University
  90. 90 University of Edinburgh
    info

    University of Edinburgh

    Edimburgo, Reino Unido

    ROR https://ror.org/01nrxwf90

  91. 91 Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center
  92. 92 University of Erlangen-Nuremberg
    info

    University of Erlangen-Nuremberg

    Erlangen, Alemania

    ROR https://ror.org/00f7hpc57

  93. 93 Department of Psychiatry, Shonan Kamakura General Hospital
  94. 94 University of Tokyo
    info

    University of Tokyo

    Tokio, Japón

    ROR https://ror.org/057zh3y96

  95. 95 Graduate School of Clinical Psychology, Teikyo Heisei University Major of Professional Clinical Psychology
  96. 96 Infectious Diseases, Genome Institute of Singapore
  97. 97 Human Genetics, Genome Institute of Singapore
  98. 98 Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine
  99. 99 Peking Union Medical College Hospital
    info

    Peking Union Medical College Hospital

    Pekín, China

    ROR https://ror.org/04jztag35

  100. 100 Center for Primary Health Care Research, Clinical Research Center, Lund University
  101. 101 University of Pisa
    info

    University of Pisa

    Pisa, Italia

    ROR https://ror.org/03ad39j10

  102. 102 University Hospital Schleswig-Holstein
    info

    University Hospital Schleswig-Holstein

    Lubeca, Alemania

  103. 103 Kiel University
    info

    Kiel University

    Kiel, Alemania

    ROR https://ror.org/04v76ef78

  104. 104 Hospital Universitario Nuestra Señora de Candelaria
    info

    Hospital Universitario Nuestra Señora de Candelaria

    Santa Cruz de Tenerife, España

    ROR https://ror.org/005a3p084

  105. 105 Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias
    info

    Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias

    Madrid, España

  106. 106 University of Chicago
    info

    University of Chicago

    Chicago, Estados Unidos

    ROR https://ror.org/024mw5h28

  107. 107 Human Genetics, Genome Institute of Singapore, A STAR
  108. 108 Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan, University School of Medicine
  109. 109 Cancer Research Center of Lyon, INSERM U1052
  110. 110 Inserm U830, Institut Curie, PSL University
  111. 111 University of Alabama at Birmingham
    info

    University of Alabama at Birmingham

    Birmingham, Estados Unidos

    ROR https://ror.org/008s83205

  112. 112 Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong
  113. 113 Department of Otolaryngology- Head and Neck Surgery, Chang Gung Memorial Hospital at Lin-Kou
  114. 114 Chang Gung University
    info

    Chang Gung University

    Taoyuan City, Taiwán

    ROR https://ror.org/00d80zx46

  115. 115 Flinders University
    info

    Flinders University

    Adelaida, Australia

    ROR https://ror.org/01kpzv902

  116. 116 School of Systems Biomedical Science, Soongsil University
  117. 117 RIKEN Advanced Science Institute
    info

    RIKEN Advanced Science Institute

    Kōbe, Japón

    ROR https://ror.org/030vbmf58

  118. 118 Division of Molecular Brain Science, Kobe University Graduate School of Medicine
  119. 119 Center for Personalized Therapeutics, University of Chicago
  120. 120 NHLBI's Framingham Heart Study
  121. 121 Population Sciences Branch, National Heart, Lung, and Blood Institute
  122. 122 Department of Genetic Medicine, Weill Cornell Medicine in Qatar
  123. 123 Wellcome Trust Sanger Institute
    info

    Wellcome Trust Sanger Institute

    Cambridge, Reino Unido

    ROR https://ror.org/05cy4wa09

  124. 124 Columbia University Medical Center
    info

    Columbia University Medical Center

    Nueva York, Estados Unidos

    ROR https://ror.org/01esghr10

  125. 125 University of Michigan Medical School
    info

    University of Michigan Medical School

    Ann Arbor, Estados Unidos

  126. 126 University of Maryland, Baltimore
    info

    University of Maryland, Baltimore

    Baltimore, Estados Unidos

    ROR https://ror.org/04rq5mt64

  127. 127 Singapore Eye Research Institute, Singapore National Eye Center
  128. 128 Department of Ophthalmology, National University of Singapore, National University Health System
  129. 129 Duke-NUS Medical School
  130. 130 Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Laboratory
  131. 131 Heidelberg University
    info

    Heidelberg University

    Heidelberg, Alemania

    ROR https://ror.org/038t36y30

Journal:
JAMA Oncology

ISSN: 2374-2445

Year of publication: 2017

Volume: 3

Issue: 5

Pages: 636-651

Type: Article

DOI: 10.1001/JAMAONCOL.2016.5945 PMID: 28241208 SCOPUS: 2-s2.0-85019502119 GOOGLE SCHOLAR
Data source: Scopus