Treatment-resistant depressionA systematic review of systematic reviews

  1. Pérez Wehbe, Alia Inés
  2. Perestelo Pérez, Lilisbeth
  3. Bethencourt Pérez, Juan Manuel
  4. Cuéllar Pompa, Leticia
  5. Peñate Castro, Wenceslao
International journal of clinical and health psychology

ISSN: 1697-2600

Año de publicación: 2014

Volumen: 14

Número: 2

Páginas: 145-153

Tipo: Artículo

DOI: 10.1016/S1697-2600(14)70048-1 DIALNET GOOGLE SCHOLAR

Otras publicaciones en: International journal of clinical and health psychology

Información de financiación

This work was supported by a grant from the Canary Islands Foundation for Health Research (FUNCIS; Exp. 51/09).

Referencias bibliográficas

  • Aguilera, A., Garza, M. J., & Muñoz, R. F. (2010). Group cognitivebehavioural therapy for depression in Spanish: culture-sensitive manualised treatment in practice. Journal of Clinical Psychology, 66, 857-867.
  • Álvarez, E., Baca, B. E., Bousoño, M., Eguiluz, I., Martín, M., Roca, M., & Urretavizcaya, M. (2008). Depresiones resistentes. Actas Españolas de Psiquiatría, 36, 35-43.
  • American Psychiatric Association, APA (2000). Diagnostic and Statistical Manual of Mental Disorders IV-TR (4th ed. rev.). Washington, DC: APA.
  • Anderson, I. M., Nutt, D. J., & Deakin, J. F. (2000) Evidence-based guidelines for treating depressive disorders with antidepressants: A revision of the 1993 British Association for Psychopharmacology guidelines. British Association for Psychopharmacology. Journal of Psychopharmacology, 14, 3-20.
  • *Barowsky, J., & Schwartz, T. L. (2006). An evidence-based approach to augmentation and combination strategies for treatment-resistant depression. Psychiatry, 3, 42-61.
  • *Bauer, M., Tharmanathan, P., Volz, H. P., Moeller, H. J., & Freemantle, N. (2009). The effect of venlafaxine compared with other antidepressants and placebo in the treatment of major depression: A meta-analysis. European Archives of Psychiatry and Clinical Neuroscience, 259, 172-185.
  • *Berlim, M. T., & Turecki, G. (2007). Definition, assessment, and staging of treatment-resistant refractory major depression: A review of current concepts and methods. Canadian Journal of Psychiatry, 52, 46-54.
  • Bretlau, L. G., Lunde, M., Lindberg, L., Unden, M., Dissing, S., & Bech, P. (2008). rTMS in combination with escitalopram in patients with treatment-resistant major depression: a doubleblind, randomised, sham-controlled trial. Pharmacopsychiatry, 41, 41-47.
  • *Bschor, J., & Baethge, C. (2010). No evidence for switching the antidepressant: systematic review and meta-analysis of RCTs of a common therapeutic strategy. Acta Psychiatrica Scandinavica, 121, 174-179.
  • *Bschor, T., & Bauer, M. (2006). Efficacy and mechanisms of action of Lithium augmentation in refractory major depression. Current Pharmaceutical Design, 2, 381-386.
  • Catafau, A. M., Perez, V., Gironell, A., Martin, J. C., Kulisevsky, J., Estorch, I., & Alvarez, E. (2001). SPECT mapping of cerebral activity changes induced by rTMS in depressed patients. A pilot study. Psychiatry Research: Neuroimaging, 106, 151-160.
  • *Daban, C., Martinez-Aran, A., Cruz, N., & Vieta, E. (2008). Safety and efficacy of vagus nerve stimulation in treatment-resistant depression. A systematic review. Journal of Affective Disorders, 110, 9-24.
  • Davidson, J. R. (2010). Major depressive disorder treatment guidelines in America and Europe. Journal of Clinical Psychiatry, 71, 4-11.
  • *Dodd, S., Horgan, D. Malhi, G. S., & Berk, M. (2005). Combine or not to combine? A literature review of antidepressant combination therapy. Journal of Affective Disorders, 89, 45-56.
  • Eby, G. A., & Eby, K. L. (2010). Magnesium for treatment-resistant depression: a review and hypothesis. Medical Hypotheses, 74, 649-660.
  • *Fekadu, A., Wooderson, S. C., Markopoulo, K., Donaldson, C., Papadopoulos, A., & Cleare, A. J. (2009). What happens to patients with treatment-resistant depression? A systematic review of medium to long term outcome studies. Journal of Affective Disorders, 116, 4-11.
  • Fernández-Ríos, L., & Buela-Casal, G. (2009). Standards for the preparation and writing of Psychology review articles. International Journal of Clinical and Health Psychology, 9, 329-344.
  • Gabriel, A. (2006). Lamotrigine adjunctive treatment in resistant unipolar depression. Depression and Anxiety, 23, 485-488.
  • Geddes, J. R., Carney, S. M., Davies, C., Fukurawa, T. A., Kupfer, D. J., Frank, E., & Goodwin, G. M. (2003). Relapse prevention with antidepressant drug treatment in depressive disorders: a systematic review. Lancet, 22, 653-661.
  • Hamilton, M. (1960). A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry, 23, 56-62.
  • Jenkins, E., & Goldner, E. M. (2012). Approaches to understanding and addressing treatment-resistant depression: A scoping review. Depression Research and Treatment, 2 [accessed 31 Jan, 2013]. Available from:
  • Kaltenthaler, E., Brazier, J., de Nigris, E., Tumur, I., Ferriter, M., Beverley, C., Parry, G., Rooney, G., & Sutcliffe, P. (2006). Computerised cognitive behaviour therapy for depression and anxiety update: a systematic review and economic evaluation. Health Technology Assessment, 10, 11-14.
  • Kennedy, S. H., & Giacobbe, P. (2007). Treatment resistant depression - Advances in somatic therapies. Annals of Clinical Psychiatry, 19, 279-287.
  • *Lam, R. W., Chan, P., Wilkins-Ho, M., & Yatham, L. N. (2008). Repetitive transcranial magnetic stimulation for treatmentresistant depression: A systematic review and metaanalysis. Canadian Journal of Psychiatry, 53, 621-631.
  • *Lam, R. W., Wan, D. D., Cohen, N. L., & Kennedy, S. H. (2002). Combining antidepressants for treatment-resistant depression: A review. Journal of Clinical Psychiatry, 63, 685-693.
  • Mahmoud, R. A., Pandina, G. J., Turkoz, I., Kosik-Gonzalez, C., Canuso, C. M., Kujawa, M. J., & Gharabawi-Garibaldi, G. M. (2007). Risperidone for treatment-refractory major depressive disorder: a randomized trial. Annual of Internal Medicine, 147, 593-562.
  • McKenna, M. T., Michaud, C. M., Murray, C. J., & Marks, J. S. (2005). Assessing the burden of disease in the United States using disability-adjusted life years. American Journal of Preventive Medicine, 28, 415-423.
  • *McPherson, S., Cairns, P., Carlyle, J., Shapiro, D. A., Richardson, P., & Taylor, D. (2005). The effectiveness of psychological treatments for treatment-resistant depression: A systematic review. Acta Psychiatrica Scandinavica, 111, 331-340.
  • Merry, S., McDowell, H., Hetrick, S., Bir, J., & Muller, N. (2004). Psychological and/or educational interventions for the prevention of depression in children and adolescents. Cochrane Database Systematic Reviews, 1, CD003380 [accessed 17 Mar 2013]. Available from:
  • Montgomery, S. A., & Asberg, M. (1979). A new depression scale designed to be sensitive to change. British Journal of Psychiatry, 134, 382-389.
  • National Institute for Health and Clinical Excellence, NICE (2009). NICE clinical guideline 90. Depression: The treatment and management of depression in adults (update) [accessed 28 Feb 2013]. Available from:
  • Nierenberg, A. A., Papakostas, G. I., Petersen, T., Montoya, H. D., Worthington, J. J., Tedlow, J., Alpert, J. E., & Fava, M. (2003). Lithium augmentation of nortriptyline for subjects resistant to multiple antidepressants. Journal of Clinical Psychopharmacology, 23, 92-95.
  • O'Reardon, J. P., Thase, M. E., & Papakostas, G. I. (2009). Pharmacological and therapeutic strategies in treatment resistant depression. Introduction and clinical presentations. CNS Spectrums, 14, 4-6.
  • Oxman, A. D., Cook, D. J., & Guyatt, G. H. (1994). User's guides to the medical literature. VI. How to use an overview. Journal of the American Medical Association, 272, 1367-1371.
  • Padberg, F., & George, M. S. (2009). Repetitive transcranial magnetic stimulation of the prefrontal cortex in depression. Expert Neurology, 219, 2-13.
  • Parker, G., Blanch, B., & Crawford, J. (2010). Does gender influence response to differing psychotherapies by those with unipolar depression? Journal of Affective Disorders, 130, 17-20.
  • Perestelo-Pérez, L. (2013). Standards on how to develop and report systematic reviews in Psychology and Health. International Journal of Clinical and Health Psychology, 13, 49-57.
  • Perestelo Pérez, L., García Pérez, L., Peñate Castro, W., Pérez Ramos, J., Rivero Santana, A., De las Cuevas Castresana, C., & González Lorenzo, M. (2010). Fármacos antidepresivos y tratamientos psicológicos para los trastornos depresivos: Una revisión y evaluación económica. Plan de Calidad para el Sistema Nacional de Salud del Ministerio de Sanidad y Política Social. Servicio de Evaluación del Servicio Canario de la Salud. Informes de Evaluación de Tecnologías Sanitarias: SESCS No 2007/16. Madrid: Ministerio de Ciencia e Innovación.
  • Rocha, F. L., & Hara, C. (2003). Lamotrigine augmentation in unipolar depression. International Clinical Psychopharmacology, 18, 97-99.
  • Ruelaz, A. R. (2006). Treatment-resistant depression: Strategies for management. Psychiatric Times, 23, 122-129.
  • *Ruhé, H. G., van Rooijen, G., Spijker, J., Peeters, F. P., & Schene, A. H. (2012). Staging methods for treatment resistant depression. A systematic review. Journal of Affective Disorders, 137, 35-45.
  • *Sarnecki, T., & Temel, Y. (2011). Deep brain stimulation for treatment-resistant depression: A review. Open Neurosurgery Journal, 4, 22-28.
  • Schlaepfer, T. E., George, M. S., & Mayberg, H. (2009). WFSBP guidelines on brain stimulation treatments in psychiatry. Journal of Biological Psychiatry, 26, 1-17.
  • Shelton, R. C., Osuntokun, O., Heinloth, A. N., & Corya, S. A. (2010). Therapeutic options for treatment-resistant depression. CNS Drugs, 24, 131-161.
  • Sobis, J., Jarzab, M., Hese, R. T., Sieron, A., Zyss, T., Gorczyca, P., Pudlo, R., & Matysiakiewicz, J. (2010). Therapeutic efficacy assessment of weak variable magnetic fields with low value of induction in patients with drug-resistant depression. Journal of Affective Disorders, 123, 321-326.
  • *Stimpson, N., Agrawal, N., & Lewis, G. (2002). Randomised controlled trials investigating pharmacological and psychological interventions for treatment-refractory depression. Systematic review. British Journal of Psychiatry, 181, 284-294.
  • Thase, M. E., & Rush, A. J. (1997). When at first you don't succeed: Sequential strategies for antidepressant nonresponders. Journal of Clinical Psychiatry, 58, 23-29.
  • *Thomas, S. P., Nandhra, H. S., & Jayaraman, A. (2010). Systematic review of lamotrigine augmentation of treatment resistant unipolar depression (TRD). Journal of Mental Health, 19, 168-175.
  • Triggs, W. J., Ricciuti, N., Ward, H. E., Cheng, J., Bowers, D., Goodman, W. K., Kluger, B. M., & Nadeau, S. E. (2010). Right and left dorsolateral pre-frontal rTMS treatment of refractory depression: a randomized, sham-controlled trial. Psychiatry Research, 178, 467-474.
  • *Trivedi, R. B., Nieuwsma, J. A., & Williams, J. W. (2011). Examination of the utility of psychotherapy for patients with treatment resistant depression: A systematic review. Journal of General Internal Medicine, 26, 643-650.
  • Vigo, D. V., & Baldessarini, R. J. (2009). Anticonvulsants in the treatment of major depressive disorder: an overview. Harvard Review in Psychiatry, 17, 231-241.
  • World Health Organization, WHO (1992). The ICD-10 classification of mental and behavioural disorders: Clinical descriptions and diagnostic guidelines. Geneva: Author.
  • World Health Organization, WHO (2005). WHO global report: Preventing chronic diseases: A vital investment. Geneva: World Health Organization [accessed 4 Apr 2013]. Available from: