Cocaína prenatal y consumo de cocaína de ratones adultos jovenes

Abstract

To evaluate the effects of Prenatal Exposure of Cocaine-EPC- (25 or 50 mg / kg / day) from 8-21 day of gestation, on oral cocaine use in female and male mice in early adulthood; was used the test of "free choice of two bottles" that measures the oral cocaine consumption in milliliters. This was evaluated for 14 consecutive days from the 7th week of age. Repeated measures MANOVA was used for the analysis of consumption. It was found that EPC 50mg/kg/day increased oral cocaine consumption in female and young adult male mice both in the acquisition and maintenance phases. And the EPC 25mg/kg/day increased the consumption only in the males in the maintenance phase, showing the greater susceptibility of these to the EPC, whereas the high cocaine consumption observed in the females was not dose-related, which can be attributed to situational factors. In this way it is seen how the EPC in the two doses evaluated increases oral cocaine consumption in early adulthood in mice; the high dose (50mg / kg) the consumption of females and males and the low dose (25mg / kg) increases the consumption only in males. It is observed that the effects are dose related and that males are more vulnerable to the effects of EPC.