Cocaine exposure during pregnancy and postpartum maternal behavior in mice

  1. María del Pilar Santacruz
  2. Rosario Josefa Marrero Quevedo
  3. Juan Manuel Bethencourt Pérez
  4. Miguel Angel Castellano Gil
  5. Wenceslao Peñate Castro
Acta Colombiana de Psicología

ISSN: 1909-9711

Year of publication: 2017

Volume: 20

Issue: 1

Pages: 166-176

Type: Article

Export: RIS
DOI: 10.14718/ACP.2017.20.1.8 DIALNET GOOGLE SCHOLAR lock_openOpen access editor


Cited by

  • Scopus Cited by: 0 (31-10-2021)

SCImago Journal Rank

  • Year 2017
  • SJR Journal Impact: 0.143
  • Best Quartile: Q4
  • Area: Psychology (miscellaneous) Quartile: Q4 Rank in area: 213/254
  • Area: Psychiatry and Mental Health Quartile: Q4 Rank in area: 452/549


  • Social Sciences: C


  • Year 2017
  • CiteScore of the Journal : 0.4
  • Area: Psychology (all) Percentile: 13
  • Area: Psychiatry and Mental Health Percentile: 12


Maternal cocaine abuse during pregnancy is associated to neglect, abuse, and mother-child bond disruption, which directly affects infant development; therefore, various neurobehavioral problems of children of drug-dependent parents could be attributed to inadequate maternal behavior or prenatal exposure to drugs. Thus, the aim of this research was to analyze the effects of chronic cocaine administration during pregnancy on postpartum maternal behavior. To do this, 21 CD1 pregnant female mice were randomly assigned for administration of saline solution and cocaine (25 mg/kg/day and 50 mg/kg/day), from day 8 to 21 of gestation. After delivery, for 15 minutes a day, during 20 days, the frequency of occurrence of 16 behavioral patterns of maternal behavior was individually recorded, using an ethogram. Cocaine slightly affected maternal behavior frequency, although it may have affected other parameters, such as latency, duration, and sequence of this behavior.

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