Early Transcriptional Liver Signatures in Experimental Visceral Leishmaniasis

  1. Dorta-Guerra, Roberto 1
  2. Carmelo, Emma 1
  3. Diaz-Solano, Raquel
  4. Palacios, Génesis 1
  5. Valladares, Basilio 1
  1. 1 Universidad de La Laguna
    info

    Universidad de La Laguna

    San Cristobal de La Laguna, España

    GRID grid.10041.34

Journal:
International Journal of Molecular Sciences

ISSN: 1422-0067

Year of publication: 2021

Volume: 22

Issue: 13

Pages: 7161

Type: Article

Export: RIS
DOI: 10.3390/ijms22137161 GOOGLE SCHOLAR

Metrics

Cited by

  • Scopus Cited by: 0 (25-11-2021)

JCR (Journal Impact Factor)

(Indicator corresponding to the last year available on this portal, year 2020)
  • Year 2020
  • Journal Impact Factor: 5.923
  • Best Quartile: Q1
  • Area: BIOCHEMISTRY & MOLECULAR BIOLOGY Quartile: Q1 Rank in area: 67/295 (Ranking edition: SCIE)
  • Area: CHEMISTRY, MULTIDISCIPLINARY Quartile: Q2 Rank in area: 49/178 (Ranking edition: SCIE)

SCImago Journal Rank

(Indicator corresponding to the last year available on this portal, year 2020)
  • Year 2020
  • SJR Journal Impact: 1.455
  • Best Quartile: Q1
  • Area: Computer Science Applications Quartile: Q1 Rank in area: 62/2196
  • Area: Inorganic Chemistry Quartile: Q1 Rank in area: 6/68
  • Area: Medicine (miscellaneous) Quartile: Q1 Rank in area: 271/2448
  • Area: Organic Chemistry Quartile: Q1 Rank in area: 15/179
  • Area: Physical and Theoretical Chemistry Quartile: Q1 Rank in area: 16/167
  • Area: Spectroscopy Quartile: Q1 Rank in area: 5/78
  • Area: Catalysis Quartile: Q2 Rank in area: 17/60
  • Area: Molecular Biology Quartile: Q2 Rank in area: 131/402

CiteScore

(Indicator corresponding to the last year available on this portal, year 2020)
  • Year 2020
  • CiteScore of the Journal : 5.7
  • Area: Inorganic Chemistry Percentile: 83
  • Area: Spectroscopy Percentile: 79
  • Area: Computer Science Applications Percentile: 78
  • Area: Physical and Theoretical Chemistry Percentile: 78
  • Area: Organic Chemistry Percentile: 77
  • Area: Molecular Biology Percentile: 61
  • Area: Catalysis Percentile: 55

Journal Citation Indicator (JCI)

(Indicator corresponding to the last year available on this portal, year 2020)
  • Year 2020
  • Journal Citation Indicator (JCI): 0.71
  • Best Quartile: Q2
  • Area: CHEMISTRY, MULTIDISCIPLINARY Quartile: Q2 Rank in area: 66/219
  • Area: BIOCHEMISTRY & MOLECULAR BIOLOGY Quartile: Q3 Rank in area: 157/311

Abstract

Transcriptional analysis of complex biological scenarios has been used extensively, even though sometimes the results of such analysis may prove imprecise or difficult to interpret due to an overwhelming amount of information. In this study, a large-scale real-time qPCR experiment was coupled to multivariate statistical analysis in order to describe the main immunological events underlying the early L. infantum infection in livers of BALB/c mice. High-throughput qPCR was used to evaluate the expression of 223 genes related to immunological response and metabolism 1, 3, 5, and 10 days post infection. This integrative analysis showed strikingly different gene signatures at 1 and 10 days post infection, revealing the progression of infection in the experimental model based on the upregulation of particular immunological response patterns and mediators. The gene signature 1 day post infection was not only characterized by the upregulation of mediators involved in interferon signaling and cell chemotaxis, but also the upregulation of some inhibitory markers. In contrast, at 10 days post infection, the upregulation of many inflammatory and Th1 markers characterized a more defined gene signature with the upregulation of mediators in the IL-12 signaling pathway. Our results reveal a significant connection between the expression of innate immune response and metabolic and inhibitory markers in early L. infantum infection of the liver.

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