Epidemiología y factores de riesgo para cuidados intensivos y mortalidad en pacientes hospitalizados por COVID-19
- Jezabel García Yanez 1
- Natacha Ayala Díaz 1
- Raquel Mª Morales Torres 1
- Carlos Rodríguez de la Rosa 1
- Arturo José Pedrero García 1
- Ana Hernández-Aceituno 1
- Natalia Rodríguez Novo 1
-
1
Hospital Universitario Nuestra Señora de Candelaria
info
Hospital Universitario Nuestra Señora de Candelaria
Santa Cruz de Tenerife, España
ISSN: 2444-8974
Year of publication: 2021
Volume: 26
Issue: 1
Pages: 17-24
Type: Article
More publications in: Revista Española de Medicina Preventiva y salud Pública
Abstract
Introduction: Complejo Hospitalario Universitario Nuestra Señora de Candelaria (CHUNSC) had the highest number of COVID-19admissions in the Canary Islands. Aim of the study was to determine the risk factors for admission to the Intensive Care Unit (ICU)and mortality.Methods: Retrospective analytical longitudinal study of patients with confirmed COVID-19, hospitalized between February 25 andMay 31, 2020, at CHUNSC.Results: In the study period, 264 patients were admitted, 56.8% men, mean age 65.3 years. Most frequent symptoms: cough (67%)and fever (59.8%), most frequent comorbidities: cardiovascular disease (60.6%) and diabetes (26.5%). Global Case Fatality Rate(CFR) 15.2%. Risk factors associated with ICU admission: Pneumonia (OR 2.22, 95%CI 1.08-4.55, p=0.029) and Acute RespiratoryDistress Syndrome (ARDS) (OR 4.94, 95%CI 1.46-16.68; p=0.010). Risk factors associated with mortality: age ≥60 years (OR 3.94,95%CI 1.21-12.82, p=0.023), pneumonia (OR 3.38, 95%CI 1.35-8.47, p=0.009), ARDS (OR 5.84, 95%CI 1.60-21.24, p=0.007) andchronic kidney disease (CKD) (OR 3.74, 95%CI 1.40-9.98, p=0.009).Conclusion: Pneumonia and ARDS were associated with ICU admission. Pneumonia, ARDS, age ≥60 years and CKD were associatedwith mortality
Bibliographic References
- [Lu H, Stratton CW, Tang YW. Outbreak of pneumonia of unknown ethiology in wuhan China: the mistery and the miracle. J Med Virol. 2020;92(4): 401-2. https://doi.org/10.1002/jmv.25678
- Instituto de Salud Carlos III. Informe nº1. Situación de COVID19 en España a 11 de febrero de 2020. Madrid: ISCIII; 2020 [citado 26 jun 2020]. Disponible en: https://www.isciii.es/QueHacemos/Servicios/VigilanciaSaludPublicaRENAVE/ EnfermedadesTransmisibles/Documents/INFORMES/Informes%20COVID-19/Informe%20COVID-19.%20 N%c2%ba%201_11febrero2020_ISCIII.pdf
- Gironés Bredy CE, Posca Maina M, Pinto Pasencia RG, Mahtani Chugani V y Grupo de Trabajo Hotel Medicalizado Tenerife Sur COVID 19. Primeras medidas de salud pública para la contención del COVID-19: cuarentena de un hotel. Emergencias. 2020;32(3): 194-196.
- Sisó-Almirall A, Kostov B, Mas-Heredia M, Vilanova-Rotllan S, Sequeira-Aymar E, Sans-Corrales M, et al. Prognostic factors in Spanish COVID-19 patients: A case series from Barcelona. PLOS ONE. 2020;15(8): e0237960. https://doi.org/10.1371/journal.pone.0237960
- Neumann-Podczaska A, Al-Saad SR, Karbowski LM, Chojnicki M, Tobia S, Wieczorowska-Tobia K. COVID 19— clinical picture in the elderly population: a qualitative systematic review. Aging Dis. 2020;11(4): 988–1008. https://doi.org/10.14336/AD.2020.0620
- Ranieri VM, Rubenfeld GD, Thompson BT, Ferguson ND, Caldwell E, Fan E, et al. Acute respiratory distress syndrome: the Berlin Definition. JAMA. 2012;307: 2526-2533. https://doi.org/10.1001/jama.2012.5669
- Ronco C, Bellomo R, Kellum JA. Acute kidney injury. Lancet. 2019;394(10212): 1949-1964. https://doi.org/10.1016/ S0140-6736(19)32563-2
- Dinarello CA, Porat R. Fiebre. En: Kasper DL,Fauci AS, Hauser SL, et al., editores. Harrison. Principios de Medicina Interna [Internet]. 19 ed. Madrid: McGraw Hill; 2016 [citado 28 julio 2020]. Disponible en: https://accessmedicina.mhmedical.com/content.aspx?bookid=1717§ionid=114909519
- Webster AC, Nagler EV, Morton RL, Masson P. Chronic Kidney Disease. Lancet. 2017 Mar 25;389(10075): 1238-1252. https://doi.org/10.1016/S0140-6736(16)32064-5
- Medeiros Figueiredo A, Daponte-Codina A, Moreira Marculino Figueiredo DC, Toledo Vianna RP, Costa de Lima K, Gil-García E. Factores asociados a la incidencia y la mortalidad por COVID-19 en las comunidades autónomas. Gac Sanit. In press. https://doi.org/doi:10.1016/j.gaceta.2020.05.004
- Martos Pérez F, Luque Del Pino J, Jiménez García N, et al. Comorbidity and prognostic factors on admission in a COVID-19 cohort of a general hospital. Rev Clin Esp. 2020;S0014-2565(20): 30179-X. https://doi.org/10.1016/j.rce.2020.05.017
- Sáenz-López JD, Sierra Rodríguez MC, García Salcedo JJ. Predictores de Mortalidad en Pacientes con COVID-19. Arch Med. 2020;16(2): 6. https://doi.org/10.3823/1429
- Pascual Gómez NF, Monge Lobo I, Granero Cremades I, et al. Potential biomarkers predictors of mortality in COVID-19 patients in the Emergency Department. Rev Esp Quimioter. 2020;33(4): 267-273. http://www.doi. org/10.37201/req/060.2020
- Sun P, Qie S, Liu Z, Ren J, Li K, Xi J. Clinical characteristics of hospitalized patients with SARS-CoV-2 infection: A single arm meta-analysis. J Med Virol. 2020;92(6): 612-617. https://doi.org/10.1002/jmv.25735
- Harapan H, Itoh N, Yufika A, et al. Coronavirus disease 2019 (COVID-19): A literature review. J Infect Public Health. 2020;13(5): 667-673. https://doi.org/10.1016/j.jiph.2020.03.019
- Singhal T. A Review of Coronavirus Disease-2019 (COVID-19). Indian J Pediatr. 2020;87(4): 281-286. https://doi.org/10.1007/s12098-020-03263-6
- Yi Y, Lagniton PNP, Ye S, Li E, Xu RH. COVID-19: what has been learned and to be learned about the novel coronavirus disease. Int J Biol Sci. 2020;16(10): 1753-1766. https://doi.org/10.7150/ijbs.45134
- Bhatraju PK, Ghassemieh BJ, Nichols M, et al. Covid-19 in Critically Ill Patients in the Seattle Region - Case Series. N Engl J Med. 2020;382(21):2012-2022. https://doi.org/10.1056/NEJMoa2004500
- Roncon L, Zuin M, Rigatelli G, Zuliani G. Diabetic patients with COVID-19 infection are at higher risk of ICU admission and poor short-term outcome. J Clin Virol. 2020;127: 104354. https://doi.org/10.1016/j.jcv.2020.104354
- Kim L, Garg S, O’Halloran A, Whitaker M, Pham H, Anderson EJ, et al. Risk Factors for Intensive Care Unit Admission and In-hospital Mortality among Hospitalized Adults Identified through the U.S. Coronavirus Disease 2019 (COVID-19)-Associated Hospitalization Surveillance Network (COVID-NET). Clin Infect Dis. 2020: ciaa1012. https://doi.org/10.1093/cid/ciaa1012
- Shahid Z, Kalayanamitra R, McClafferty B, et al. COVID-19 and Older Adults: What We Know. J Am Geriatr Soc. 2020;68(5): 926-929. https://doi.org/10.1111/jgs.16472
- Cheng Y, Luo R, Wang K, et al. Kidney disease is associated with in-hospital death of patients with COVID-19. Kidney Int. 2020;97(5): 829-838. https://doi.org/10.1016/j.kint.2020.03.005
- Henry BM, Lippi G. Chronic kidney disease is associated with severe coronavirus disease 2019 (COVID-19) infection. Int Urol Nephrol. 2020;52(6): 1193-1194. https://doi.org/10.1007/s11255-020-02451-9
- Ramallo-Fariña Y, García-Pérez L, Castilla-Rodríguez I. et al. Effectiveness and cost-effectiveness of knowledge transfer and behavior modification interventions in type 2 diabetes mellitus patients—the INDICA study: a cluster randomized controlled trial. Implementation Sci. 2015;10: 47. https://doi.org/10.1186/s13012-015-0233-1
- Giesen C, Diez-Izquierdo L, Saa-Requejo CM, et al. Epidemiological characteristics of the COVID-19 outbreak in a secondary hospital in Spain. Am J Infect Control. 2020;S0196-6553(20): 30700-8. https://doi.org/10.1016/j.ajic.2020.07.014
- Hamid S, Mir MY, Rohela GK. Novel coronavirus disease (COVID-19): a pandemic (epidemiology, pathogenesis and potential therapeutics). New Microbes New Infect. 2020;35: 100679. https://doi.org/10.1016/j.nmni.2020.100679
- Ministerio de sanidad. Actualización nº 167. Enfermedad por el coronavirus (COVID-19). 21.07.2020. Ministerio de Sanidad. Gobierno de España, 2020.