Study of the Etiology of Acute Respiratory Infections in Children Under 5 Years at the Dr. Agostinho Neto Hospital, Praia, Santiago Island, Cabo Verde

  1. Correia, Wilson
  2. Sanches, Mitza
  3. Almeida Semedo, Carmen de Jesús Borges
  4. Dorta-Guerra, Roberto 1
  5. Carmelo, Emma 1
  6. Valladares, Basilio 1
  7. de Pina-Araújo, Isabel Inês M.
  1. 1 Universidad de La Laguna
    info

    Universidad de La Laguna

    San Cristobal de La Laguna, España

    ROR https://ror.org/01r9z8p25

Revista:
Frontiers in Pediatrics

ISSN: 2296-2360

Ano de publicación: 2021

Volume: 9

Tipo: Artigo

DOI: 10.3389/FPED.2021.716351 GOOGLE SCHOLAR

Outras publicacións en: Frontiers in Pediatrics

Resumo

Background: Acute respiratory infections are one of the major causes of morbidity and mortality in children under 5 years in developing countries and are a challenge for the health system of these countries. In Cabo Verde, despite the lack of recent studies, data indicate that it affects thousands of children, being the fourth leading cause of infant mortality in 2013. The aim of this study was to identify and describe the etiological agents associated with acute respiratory tract infections in children under 5 years old, and their associated risk factors, such as clinical symptoms or socio-demographic characteristics.Methods: Naso-pharyngeal samples were collected from children under 5 years attending at Dr. Agostinho Neto Hospital (Praia, Santiago Island, Cabo Verde) with suspected ARI at different time-points during 2019. Samples were analyzed using FilmArray® Respiratory Panel v. 2.0 Plus to identify etiological agents of ARI. A questionnaire with socio-demographic information was also collected for each participant. Data analyses were carried out using the IBM SPSS version 25 (IBM Corporation, Armonk, NY) and R 3.5.1 statistical software.Results: A total of 129 naso-pharyngeal samples were included in the study. Seventeen different etiologic agents of respiratory infections were identified. HRV/EV was the most frequent agent detected, followed by FluA H3 and RSV. Coinfection with two or more pathogens was detected in up to 20% of positive samples. The results were analyzed in terms of age-group, sex, period of the year and other social and demographic factors.Conclusion: Viruses are the main causative agents of ARI in children <5 years attending at the pediatrics service at the Dr. Agostinho Neto Hospital in Praia city, Santiago Island, Cabo Verde. Some factors are described in this study as statistically associated with the presence of an infectious agent, such as having one or more children sharing the bedroom with an adult and the presence of some clinical symptoms. The data addresses the need for studies on respiratory tract infections in Cabo Verde.

Referencias bibliográficas

  • Filho, (2017), Revita FIMCA, 4, pp. 7, 10.37157/fimca.v4i1.5
  • Azevedo, (2015), Rev Bras Meteorol, 30, pp. 467, 10.1590/0102-778620140066
  • Babady, (2018), J Clin Microbiol, 10.1128/JCM.01658-17
  • Heikkinen, (2003), Lancer, 361, pp. 51, 10.1016/S0140-6736(03)12162-9
  • Marcone, (2015), RE Argent Microbiol Argent Microbiol, 47, pp. 29, 10.1016/j.ram.2014.12.003
  • Bhuyan, (2017), PLoS ONE, 12, pp. e0174488, 10.1371/journal.pone.0174488
  • Lagare, (2015), BMC Infect Dis, 15, pp. 515, 10.1186/s12879-015-1251-y
  • Li, (2018), BMC Infect Dis, 18, pp. 510, 10.1186/s12879-018-3429-6
  • Kenmoe, (2016), Influ Other Respir Virus, 10, pp. 386, 10.1111/irv.12391
  • Peeri, (2020), Int J Epidemiol, 49, pp. 717, 10.1093/ije/dyaa033
  • (2019), Heal Sci Rep, 2, pp. 137, 10.1002/hsr2.137
  • Duarte, (2021), J Med Virol, 93, pp. 4756, 10.1002/jmv.26822
  • Pscheidt, (2021), Rev Med Virol, 31, pp. e2189, 10.1002/rmv.2189
  • Rowlinson, (2017), Influenza Other Respir Viruses, 11, pp. 23, 10.1111/irv.12409
  • Fitzner, (2018), Policy Pratct, 96, pp. 122, 10.2471/BLT.17.194514
  • Tazinya, (2018), BMC Pulm Med, 18, pp. 7, 10.1186/s12890-018-0579-7
  • (2010), World Health Statistics, pp. 273
  • Chen, (2018), BMC Pediatr, 18, pp. 216, 10.1186/s12887-018-1203-y
  • PraiaInstituto Nacional de Estatística (INE)2010
  • (2017), Plano Nacional de Desenvolvimento Sanitário 2017-2021, Vol. I, pp. 109
  • Cabo Verde: WHO Statistical Profile2015
  • (2019), Relatório Estatístico 2018, pp. 164
  • Dia, (2013), Am Soc Trop Med Hyg, 88, pp. 946, 10.4269/ajtmh.12-0401
  • Baden, (2009), N Engl J Med, 360, pp. 2667, 10.1056/NEJMe0903992
  • Botti, (2018), Exp Ther Med, 15, pp. 4805, 10.3892/etm.2018.6061
  • Mckinley, (2018), J Clin Microbiol, 56, pp. 1, 10.1128/JCM.01945-17
  • Kaku, (2018), J Infect Chemother, 24, pp. 734, 10.1016/j.jiac.2018.05.006
  • Hoffmann, (2012), PLoS ONE, 7, pp. e43666, 10.1371/journal.pone.0043666
  • Khor, (2012), BMC Pediatr, 12, pp. 32, 10.1186/1471-2431-12-32
  • Kwofie, (2012), Virol J, 9, pp. 78, 10.1186/1743-422X-9-78
  • Bezerra, (2011), PLoS ONE, 6, pp. e18928, 10.1371/journal.pone.0018928
  • Tsagarakis, (2018), Medicine (Baltimore), 97, pp. e10903, 10.1097/MD.0000000000010903
  • Krammer, (2018), Nat Rev Dis Prim, 4, pp. 3, 10.1038/s41572-018-0002-y
  • Simusika, (2015), BMC Infect Dis, 15, pp. 52, 10.1186/s12879-015-0779-1
  • Wong-Chew, (2017), Int J Infect Dis, 62, pp. 32, 10.1016/j.ijid.2017.06.020
  • To, (2017), J Formos Med Assoc, 116, pp. 496, 10.1016/j.jfma.2017.04.009
  • Luniewska, (2019), Adv Exp Med Biol Clin Exp Biomed, 7, pp. 97, 10.1007/5584_2019_393
  • Odun-Ayo, (2018), Afr Health Sci, 18, pp. 1134, 10.4314/ahs.v18i4.34
  • Turbelin, (2013), PLoS ONE, 8, pp. e65919, 10.1371/journal.pone.0065919
  • Wong, (2019), BMC Infect Dis, 19, pp. 42, 10.1186/s12879-019-3681-4
  • Beauté, (2015), Epidemiol Infect, 143, pp. 2950, 10.1017/S0950268814003422
  • Bakir, (2020), Arch Argent Pediatr, 118, pp. 193, 10.5546/aap.2020.eng.193
  • Liu, (2015), BMC Infect Dis, 15, pp. 408, 10.1186/s12879-015-1126-2
  • Wu, (2020), Medicine (Baltimore), 99, pp. 4, 10.1097/MD.0000000000018584
  • Zhao, (2020), J Clin Virol, 123, pp. 104254, 10.1016/j.jcv.2019.104254
  • Chau, (2014), Eur J Pediatr, 173, pp. 291, 10.1007/s00431-013-2127-z
  • Gregianini, (2019), J Med Virol, 91, pp. 1423, 10.1002/jmv.25459
  • Breiman, (2015), BCM Infect Dis, 15, pp. 95, 10.1186/s12879-015-0827-x
  • Caini, (2020), J Infect Public Heath, 12, pp. 357, 10.1016/j.jiph.2018.12.003
  • Çiçek, (2015), Mikrobiyol Bul, 49, pp. 188, 10.5578/mb.9024
  • Alonso, (2007), Am J Epidemiol, 165, pp. 1434, 10.1093/aje/kwm012
  • Chit, (2006), PLoS Med, 3, pp. e121, 10.1371/journal.pmed.0030121
  • Blasi, (2004), Eur Respir J, 24, pp. 171, 10.1183/09031936.04.00135703
  • Choroszy-Król, (2014), Adv Clin Exp Med, 23, pp. 123, 10.17219/acem/37035
  • Esposito, (2001), Eur Respir J, 17, pp. 241, 10.1183/09031936.01.17202410
  • Chen, (2017), Biomed Res Int, 2017, pp. 7320859, 10.1155/2017/7320859
  • Johnston, (2005), Am J Respir Crit Care Med, 172, pp. 1078, 10.1164/rccm.200412-1743PP
  • Trombetta, (2016), Pathog Glob Health, 110, pp. 1, 10.1080/20477724.2016.1181294
  • Lusignan, (2020), Lancet Infect Dis, 20, pp. 1034, 10.1016/S1473-3099(20)30371-6
  • Uddin, (2018), Clin Infect Dis, 67, pp. 1507, 10.1093/cid/ciy317
  • Atwell, (2016), J Infect Dis, 214, pp. 1712, 10.1093/infdis/jiw447
  • Leung, (2020), Mech Ageing Dev, 188, pp. 111255, 10.1016/j.mad.2020.111255
  • Macedo SEC, (2007), Rev Saude Publica, 41, pp. 351, 10.1590/S0034-89102007000300005
  • Yamamoto, (2016), Medicine (Baltimore), 95, pp. e3628, 10.1097/MD.0000000000003628
  • Amesty, (2020), Ophthalmol Ther, 9, pp. 415, 10.1007/s40123-020-00260-y
  • Backus, (2011), Curr Cardiol Rev, 7, pp. 2, 10.2174/157340311795677662
  • Paichadze, (2015), BMC Emerg Med, 10.1186/1471-227X-15-S2-S13
  • Parsonage, (2013), Med J Aust, 199, pp. 30, 10.5694/mja12.11171
  • Cox, (2017), Influ Other Respir Viruses, 11, pp. 489, 10.1111/irv.12481
  • Dagne, (2020), BMC Pediatr, 20, pp. 93, 10.1186/s12887-020-1997-2
  • Sonego, (2015), PLoS ONE, 10, pp. e0116380, 10.1371/journal.pone.0116380
  • Dickson, (2015), Glob Heath Action, 8, pp. 29349, 10.3402/gha.v8.29349