Serum Sclerostin and Muscle Strength in Alcoholics

  1. Emilio González Reimers 1
  2. Lucía Romero-Acevedo 1
  3. Geraldine Quintero-Platt 1
  4. Candelaria Martín-González 1
  5. Patricia Cabrera-García 1
  6. Mª Ángeles Gómez-Rodríguez 1
  7. Elisa Espelosín Ortega 2
  8. Francisco Santolaria-Fernández 1
  1. 1 Hospital Universitario de Canarias

    Hospital Universitario de Canarias

    San Cristóbal de La Laguna, España


  2. 2 Laboratorio Central Hospital Universitario de Canarias. Universidad de La Laguna, Tenerife, Spain
Journal of Musculoskeletal Disorders and Treatment

ISSN: 2572-3243

Year of publication: 2017

Volume: 3

Issue: 1

Type: Article

More publications in: Journal of Musculoskeletal Disorders and Treatment


Chronic alcoholic myopathy is a common complication of alcoholism, leading to muscle atrophy and reduced muscle strength. Sclerostin inhibits bone synthesis in situations of reduced load, such as prolonged bed rest or spinal cord injury. The aim pf this study is to analyze the behavior of serum sclerostin in chronic alcoholic myopathy.

Bibliographic References

  • Baron R, Rawadi G (2007) Targeting the Wnt/beta-catenin pathway to regulate bone formation in the adult skeleton. Endocrinology 148: 2635-2643.
  • Battaglino RA, Lazzari AA, Garshick E, Morse LR (2012) Spinal cord injury-induced osteoporosis: pathogenesis and emerging therapies. Curr Osteoporos Rep 10: 278-285.
  • Spatz JM, Wein MN, Gooi JH, Qu Y, Garr JL, et al. (2015) The Wnt inhibitor Sclerostin is up-regulated by mechanical unloading in osteocytes in vitro. J Biol Chem 290: 16744-16758.
  • Preedy VR, Paice A, Mantle D, Dhillon AS, Palmer TN, et al. (2001) Alcoholic myopathy: biochemical mechanisms. Drug Alcohol Depend 63: 199-205.
  • Alvisa-Negrín J, González-Reimers E, Santolaria-Fernández F, GarcíaValdecasas-Campelo E, Alemán-Valls MR et al. (2009) Osteopenia in alcoholics: effect of alcohol abstinence. Alcohol Alcohol 44: 468-47
  • Diamond T, Stiel D, Lunzer M, Wilkinson M, Posen S (1989) Ethanol reduces bone formation and may cause osteoporosis. Am J Med 86: 282-288.
  • Dai J, Lin D, Zhang J, Habib P, Smith P, et al. (2000) Chronic alcohol ingestion induces osteoclastogenesis and bone loss through IL-6 in mice. J Clin Invest 106: 887-895.
  • González-Reimers E, Martín-González C, de la Vega-Prieto MJ, PelazasGonzález R, Fernández-Rodríguez C, et al. (2013) Serum sclerostin in alcoholics: a pilot study. Alcohol Alcohol 48: 278-282.
  • Rhee Y, Kim WJ, Han KJ, Lim SK, Kim SH (2014) Effect of liver dysfunction on circulating sclerostin. J Bone Miner Metab 32: 545-549.
  • Grasso D, Corsetti R, Lanteri P, Di Bernardo C, Colombini A, et al. (2015) Bone-muscle unit activity, salivary steroid hormones profile, and physical effort over a 3-week stage race. Scand J Med Sci Sports 25: 70-80.
  • Urbano-Marquez A, Estruch R, Navarro-Lopez F, Grau JM, Mont L, et al. (1989) The effects of alcoholism on skeletal and cardiac muscle. N Engl J Med 320: 409-415.
  • Preedy VR, Peters TJ (1990) Alcohol and skeletal muscle disease. Alcohol Alcohol 25: 177-187.
  • Preedy VR, Salisbury JR, Peters TJ (1994) Alcoholic muscle disease: features and mechanisms. J Pathol 173: 309-315.
  • Romero JC, Santolaria F, González-Reimers E, Dìaz-Flores L, Conde A, et al. (1994) Chronic alcoholic myopathy and nutritional status. Alcohol 11: 549- 555.
  • Arteh J, Narra S, Nair S (2010). Prevalence of vitamin D deficiency in chronic liver disease. Dig Dis Sci 55: 2624-2628.
  • Fernandez-Solà J, Preedy VR, Lang CH, Gonzalez-Reimers E, Arno M, et al. (2007) Molecular and cellular events in alcohol-induced muscle disease. Alcohol Clin Exp Res 31: 1953-1962.