Does female with chromosome translocation have a normal response to controlled ovarian hyperstimulation?

  1. Kaddouri-Kaddouri, Salma 1
  2. Concepción-Lorenzo, Cintia
  3. Rodríguez-Díaz, Rubí N 1
  4. Hess-Medler, Stephany
  5. González-Pérez, Jonay
  6. Vaca-Sánchez, Rebeca
  7. Báez-Quintana, Delia R
  8. Blanes-Zamora, Raquel
  1. 1 Universidad de La Laguna

    Universidad de La Laguna

    San Cristobal de La Laguna, España


International Research Journal of Medicine and Medical Sciences

ISSN: 2354-211X

Year of publication: 2020

Volume: 8

Issue: 4

Pages: 109-115

Type: Article

DOI: 10.30918/IRJMMS.84.20.043 GOOGLE SCHOLAR lock_openOpen access editor

More publications in: International Research Journal of Medicine and Medical Sciences


Patients with chromosomal translocation have been reported to have high risk of reproductive failure, lower ovarian response, recurrent pregnancy loss and implantation failure. The literature is not conclusive, and our objective is to study if female balanced translocation (BT) does affect the controlled ovarian stimulation (COS). We carried out a retrospective analysis of 3249 karyotypes between 2008 and 2016, including 2276 females and 973 males. 12 women (0.5%) with BT were compared with 93 control normal karyotype group (CN) in both female and male partner. An equivalent control group (EQc) of 12 patients was additionally selected to be accurate with the BT statistical contrast. Cycle, oocyte and embryo outcomes were analysed. We concluded that female BT carriers have no diminished response to COS than infertile females with normal karyotype. This is an important information for counselling couples previous to COS and preimplantational genetic testing (PGT).