Oxidative Damage and Telomere Length as Markers of Lung Cancer Development among Chronic Obstructive Pulmonary Disease (COPD) Smokers

  1. Córdoba-Lanús, Elizabeth 234
  2. Montuenga, Luis M. 9101112
  3. Domínguez-de-Barros, Angélica 3
  4. Oliva, Alexis 36
  5. Mayato, Delia 7
  6. Remírez-Sanz, Ana 9
  7. Gonzalvo, Francisca 7
  8. Celli, Bartolomé 5
  9. Zulueta, Javier J. 1
  10. Casanova, Ciro 278
  1. 1 Pulmonary, Critical Care and Sleep Medicine Division, Mount Sinai Morningside Hospital, Icahn School of Medicine, New York, NY 10025, USA
  2. 2 Department of Internal Medicine, Dermatology and Psychiatry, University of La Laguna, 38296 San Cristóbal de La Laguna, Spain
  3. 3 Instituto de Enfermedades Tropicales y Salud Pública de Canarias (IUETSPC), 38029 San Cristóbal de La Laguna, Spain
  4. 4 Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, 28029 Madrid, Spain
  5. 5 Pulmonary Critical Care Medicine Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
  6. 6 Department of Pharmaceutical Technology, University of La Laguna, 38296 San Cristóbal de La Laguna, Spain
  7. 7 Pulmonary Division, Research Unit, Hospital Universitario Nuestra Señora de Candelaria, 38010 Santa Cruz de Tenerife, Spain
  8. 8 Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, 28029 Madrid, Spain
  9. 9 CIMA—Centro de Investigación Médica Aplicada, University of Navarra, 31008 Pamplona, Spain
  10. 10 Department of Pathology, Anatomy and Physiology, School of Medicine and Sciences, University of Navarra, 31008 Pamplona, Spain
  11. 11 Navarra Institute for Health Research (IdISNA), 31008 Pamplona, Spain
  12. 12 Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), 28029 Madrid, Spain
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Revista:
Antioxidants

ISSN: 2076-3921

Año de publicación: 2024

Volumen: 13

Número: 2

Páginas: 156

Tipo: Artículo

DOI: 10.3390/ANTIOX13020156 GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: Antioxidants

Resumen

Lung cancer (LC) constitutes an important cause of death among patients with Chronic Obstructive Pulmonary Disease (COPD). Both diseases may share pathobiological mechanisms related to oxidative damage and cellular senescence. In this study, the potential value of leucocyte telomere length, a hallmark of aging, and 8-OHdG concentrations, indicative of oxidative DNA damage, as risk biomarkers of LC was evaluated in COPD patients three years prior to LC diagnosis. Relative telomere length measured using qPCR and serum levels of 8-OHdG were determined at the baseline in 99 COPD smokers (33 with LC and 66 age-matched COPD without LC as controls). Of these, 21 COPD with LC and 42 controls had the biomarkers measured 3 years before. Single nucleotide variants (SNVs) in TERT, RTEL, and NAF1 genes were also determined. COPD cases were evaluated, which showed greater telomere length (p < 0.001) and increased serum 8-OHdG levels (p = 0.004) three years prior to LC diagnosis compared to the controls. This relationship was confirmed at the time of LC diagnosis. No significant association was found between the studied SNVs in cases vs. controls. In conclusion, this preliminary study shows that longer leucocyte telomere length and increased 8-OHdG serum levels can be useful as early biomarkers of the risk for future lung cancer development among COPD patients.

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Información de financiación

Financiadores

  • Instituto de Salud Carlos III
    • PI 12/00355
  • European Regional Development Fund
  • Spanish Respiratory Society, SEPAR
    • PI 13/007
  • Menarini Laboratory S.A.
  • Cabildo de Tenerife, Tenerife 2030, FDCAN, MEDI
  • Consorcio Centro de Investigación Biomédica en Red de Enfermedades Infecciosas CIBERINFEC
    • CB21/13/00100
  • Instituto de Salud Carlos III, Spain

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